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Vet Comp Orthop Traumatol 2006; 19(04): 239-245
DOI: 10.1055/s-0038-1633007
Clinical Communication
Schattauer GmbH

Surgery plus chondroprotection for canine cranial cruciate ligament (CCL) rupture

A proton-NMR study
A. Crovace
1   Emergency and Organ Transplantation Department (D.E.T.O.), Veterinary Surgery Division, University of Bari, Valenzano, Italy
,
L. Lacitignola
2   Faculty of Veterinary Medicine, Department of Veterinary Clinical Sciences, University of Teramo, Italy
,
A. Miolo
3   Scientific Documentation and Information Centre (CeDIS), Innovet Italia srl, Rubano, Italy
,
F. P. Fanizzi
4   Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, Università di Lecce, Lecce, Italy
5   Consortium C.A.R.S.O. Cancer Research Center, Bari, Italy
› Author Affiliations
Further Information

Publication History

Received 26 January 2006

Accepted 24 March 2006

Publication Date:
22 February 2018 (online)

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Summary

Rupture of the cranial cruciate ligament (CCL) is one of the most frequent causes of lameness of the rear limb in the dog. Regardless of the type of treatment, CCL rupture inevitably leads to knee osteoarthritis (OA). The purpose of this study was to evaluate the efficacy of associating surgical treatment of spontaneous rupture of the CCL with a chondroprotector, that is called “supraadditive” because it is formulated to counteract not only chondrodegeneration, but also the oxidative and inflammatory processes of OA. The open-label controlled study used proton NMR spectroscopy to evaluate the synovial fluid of the stifle of 10 dogs with monolateral rupture of the CCL, selected for the study based on specific inclusive criteria. The dogs were assigned randomly into two groups. Five dogs received the supra-additive chondroprotector for 60 days, starting on the day after surgery. Five dogs only underwent surgical reconstruction of the CCL. The results were analysed with the ANOVA unstructured variance matrix-covariance test. The trend overtime of the synovial concentration of four metabolites (lactate, alanine, acetyl groups of N-acety-lated sugars on glycoproteins and alpha-anomers of glucose) was found to differ to a statistically significant extent between the two groups, suggesting that the supra-additive chondroprotector produces an intra-ar-ticular metabolic rebalance. The results support the adjuvant use of the chondroprotector in the management of CCL rupture, in view of its control of the OA changes that accompany this orthopaedic disabling condition.

Keywords

Osteoarthritis - dogs - cranial cruciate ligament - chondroprotection - spectroscopy

* This pdf has been corrected on Jan. 15,2015 based on Corrigendum published in Vet Comp Orthop Traumatol 2007; 20:149.


 

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