Therapieoption mit Botulinumtoxin für Patienten mit Parkinson

Zusammenfassung

Im Schatten der anderen Therapieoptionen bei Parkinson-Syndromen hat sich die Injektion von Botulinumtoxin für eine Reihe von Indikationen zum unverzichtbaren Helfer gemacht. Hierzu gehören vor allem die Sialorrhoe des Parkinson-Patienten und therapierefraktäre Dystonien des Gesichtes (Blepharospasmus) sowie der Extremitäten (Off-Dystonien). Der Beitrag nennt die Indikation, die verfügbare Evidenz und eine pragmatische Herangehensweise. Die Empfehlung der Autoren zu jeder Indikation sowie deren Zulassungsstatus wird benannt.

Summary

In the backwater of the other therapy modalities for Parkinson syndromes, botulinum toxin type A injection has evolved as a notto-miss option for a number of indications. These are sialorrhea of patients with Parkinson’s disease and therapy-refractory dystonia of the face (blepharospasm) or the extremities (off dystonia). The paper reports the indications, the available evidence, and a pragmatic approach. The authors’ recommendations are given as well as the label status of the various indications.

Schlüsselwörter

Parkinson - Botulinumtoxin - Dystonie - Sialorrhoe

Keywords

Parkinson’s disease - botulinum toxin - dystonia - sialorrhea

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