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Nervenheilkunde 2014; 33(05): 319-324
DOI: 10.1055/s-0038-1633398
Editorial
Schattauer GmbH

Chemo-Gehirn

Nebenwirkungen von Chemotherapie im Erleben, Denken, Fühlen und Handeln
M. Spitzer
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Publication History

Publication Date:
02 February 2018 (online)

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  • Literatur

  • 1 Abraham J. et al. Adjuvant chemotherapy for breast cancer: Effects on cerebral white matter seen in diffusion tensor imaging. Clin Breast Cancer 2008; 08: 88-91.
    CrossrefPubMedSearch in Google Scholar
  • 2 Ahles TA, Saykin AJ. Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 2007; 07: 192-201.
    CrossrefPubMedSearch in Google Scholar
  • 3 Ahles TA. et al. Cognitive function in breast cancer patients prior to adjuvant treatment. Breast Cancer Res Treat 2008; 110: 143-152.
    CrossrefPubMedSearch in Google Scholar
  • 4 Beltagya MEL. et al. Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil. Behavioural Brain Research 2012; 208: 112-117.
    Search in Google Scholar
  • 5 Campbell K. Can exercise improve cancer associated cognitive dysfunction?. (chemobrain) ClinicalTrials.gov Identifier: NCT01296893. 2012
    PubMedSearch in Google Scholar
  • 6 Cimprich B. et al. Prechemotherapy alterations in brain function in women with breast cancer. J Clin Exp Neuropsychol 2010; 32: 324-331.
    CrossrefPubMedSearch in Google Scholar
  • 7 Correa DD, Ahles TA. Neurocognitive changes in cancer survivors. Cancer J 2008; 14: 396-400.
    CrossrefPubMedSearch in Google Scholar
  • 8 de Ruiter MB. et al. Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Hum Brain Mapp 2011; 32: 1206-1219.
    CrossrefPubMedSearch in Google Scholar
  • 9 de Ruiter MB. et al. Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. Hum Brain Mapp 2012; 33: 2971-2983.
    CrossrefPubMedSearch in Google Scholar
  • 10 Dietrich J. et al. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol 2006; 05: 22.
    CrossrefPubMedSearch in Google Scholar
  • 11 Dietrich J. et al. Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist 2008; 13: 1285-1295.
    CrossrefPubMedSearch in Google Scholar
  • 12 Erickson KI. et al. Exercise training increases size of hippocampus and improves memory. PNAS 2011; 108: 3017-22.
    CrossrefPubMedSearch in Google Scholar
  • 13 Ernst A. et al. Neurogenesis in the striatum of the adult human brain. Cell 2014; 156: 1072-1083.
    CrossrefPubMedSearch in Google Scholar
  • 14 Fardell JE. et al. Chemotherapy and cognitive impairment: treatment options. Clin Pharmacol Ther 2011; 90: 366-376.
    CrossrefPubMedSearch in Google Scholar
  • 15 Ferguson RJ. et al. Development of CBT for chemotherapy-related cognitive change: results of a waitlist control trial. Psycho Oncology 2012; 21: 176-186.
    CrossrefPubMedSearch in Google Scholar
  • 16 Han R. et al. Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system. J Biol 2008; 07: 12.
    CrossrefPubMedSearch in Google Scholar
  • 17 Hermelink K. et al. Cognitive function during neoadjuvant chemotherapy for breast cancer: results of a prospective, multicenter, longitudinal study. Cancer 2007; 109: 1905-13.
    CrossrefPubMedSearch in Google Scholar
  • 18 Inagaki M. et al. Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer 2007; 109: 146-156.
    CrossrefPubMedSearch in Google Scholar
  • 19 Jenkins V. et al. A 3-year prospective study of the effects of adjuvant treatments on cognition in women with early stage breast cancer. Br J Cancer 2006; 94: 828-834.
    CrossrefPubMedSearch in Google Scholar
  • 20 Kesler SR. et al. Regional brain activation during verbal declarative memory in metastatic breast cancer. Clin Cancer Res 2009; 15: 6665-6673.
    CrossrefPubMedSearch in Google Scholar
  • 21 Kesler SR, Kent JS, O’Hara R. Prefrontal cortex and executive function impairments in primary breast cancer. Arch Neurol 2011; 68: 1447-1453.
    CrossrefPubMedSearch in Google Scholar
  • 22 Lyons L. et al. Fluoxetine counteracts the cognitive and cellular effects of 5-Fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery. PLoS ONE. 2012 07. (01): e30010 doi:10.1371/journal.pone.0030010.
    Search in Google Scholar
  • 23 McDonald BC. et al. Gray matter reduction associated with systemic chemotherapy for breast cancer: A prospective MRI study. Breast Cancer Res Treat 2010; 123: 819-828.
    CrossrefPubMedSearch in Google Scholar
  • 24 McNeely ML. et al. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ 2006; 175: 34-41.
    CrossrefPubMedSearch in Google Scholar
  • 25 Mignone RG, Weber ET. Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA. Brain Res 2006; 1111: 26-29.
    CrossrefPubMedSearch in Google Scholar
  • 26 Naylor AS. et al. Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. PNAS 2008; 105: 14632-7.
    CrossrefPubMedSearch in Google Scholar
  • 27 Rodgers SP. et al. Neurogenesis, exercise, and cognitive late effects of pediatric radiotherapy. Neural Plasticity. 2013 Article ID 698528, 12 pages; http://dx.doi.org/10.1155/2013/698528 .
    CrossrefPubMedSearch in Google Scholar
  • 28 Santarelli L. et al. Requirement of hippocampal neurogenesis fort he behavioral effects of antidepressants. Science 2003; 301: 805-809.
    CrossrefPubMedSearch in Google Scholar
  • 29 Schagen SB. et al. Change in cognitivc function after chemotherapy: A prospective longitudinal study in breast caneer patients. J Natl Canc Inst 2006; 98: 1742-1745.
    Search in Google Scholar
  • 30 Schagen SB, Vardy J. Cognitive dysfunction in people with cancer. Lancet Oncol 2007; 08: 852-53.
    CrossrefPubMedSearch in Google Scholar
  • 31 Scherwath A. et al. Neuropsychological function in high-risk breast cancer survivors after stem-cell supported high-dose therapy versus standard-dose chemotherapy: evaluation of long-term treatment effects. Ann Oncol 2006; 17: 415-423.
    CrossrefPubMedSearch in Google Scholar
  • 32 Seigers R, Fardell JE. Neurobiolgical basis of chemotherapy-induced cognitive impairment: a review of rodent research. Neurosci Biobehav Rev 2011; 35: 729-741.
    CrossrefPubMedSearch in Google Scholar
  • 33 Seigers R. et al. Methotrexate decreases hippocampal cell proliferation and induces memory deficits in rats. Behav Brain Res 2009; 201: 279-284.
    CrossrefPubMedSearch in Google Scholar
  • 34 Silverman DHS. et al. Altered frontocortical, cerebellar, and basal ganglia activity in adjuvanttreated breast cancer survivors 5–10 years after chemotherapy. Breast Cancer Res Treat 2007; 103: 303-311.
    CrossrefPubMedSearch in Google Scholar
  • 35 Spalding KL. et al. Dynamics of hippocampal neurogenesis in adult humans. Cell 2013; 153: 1219-27.
    CrossrefPubMedSearch in Google Scholar
  • 36 Spitzer M. Zwei Sprachen sind gesund!. Nervenheilkunde 2014; 33: 180-189.
    Thieme ConnectSearch in Google Scholar
  • 37 Sullivan EV, Rohlfing T, Pfefferbaum A. Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: Relations to timed performance. Neurobiol Aging 2010; 31: 464-481.
    CrossrefPubMedSearch in Google Scholar
  • 38 Vardy J, Rourke S, Tannock IF. Evaluation of cognitiv function associated with chemotherapy: a review of published studies and recommendations for future research. J Clin Oncol 2007; 25: 2455-63.
    CrossrefPubMedSearch in Google Scholar
  • 39 Von Ah D. et al. Putting evidence into practice: evidence-based interventions for cancer and cancer treatment-related cognitive impairment. Clin J Oncol Nurs 2011; 15: 607-615.
    CrossrefPubMedSearch in Google Scholar
  • 40 Wefel JS. et al. The cognitive sequelae of standarddose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer 2004; 100: 2292-9.
    CrossrefPubMedSearch in Google Scholar
  • 41 Wefel JS. et al. Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer 2010; 116: 3348-3356.
    CrossrefPubMedSearch in Google Scholar
  • 42 Wefel JS, Schagen SB. Chemotherapy-related cognitive dysfunction. Curr Neurol Neurosci Rep 2012; 12: 267-275.
    CrossrefPubMedSearch in Google Scholar
  • 43 Weis J, Poppelreuter M, Bartsch HH. Cognitive deficits as long-term side-effects of adjuvant therapy in breast cancer patients: ‘Subjective’ complaints and ‘objective’ neuropsychological test results. Psychooncology 2009; 18: 775-782.
    CrossrefPubMedSearch in Google Scholar
  • 44 Wong-Goodrich SJE. et al. Voluntary running prevents progressive memory decline and increases adult hippocampal neurogenesis and growth factor expression after whole-brain irradiation. Cancer Research 2010; 70: 9329-9338.
    CrossrefPubMedSearch in Google Scholar
  • 45 Yoshikawa E. et al. No adverse effects of adjuvant chemotherapy on hippocampal volume in Japanese breast cancer survivors. Breast Canc Res Treat 2005; 92: 81-84.
    CrossrefPubMedSearch in Google Scholar
  • 46 Kreukels BP. et al. Effects of high-dose and conventional-dose adjuvant chemotherapy on longterm cognitive sequelae in patients with breast cancer: an electrophysiologic study. Clin Breast Cancer 2006; 07: 67-78.
    CrossrefPubMedSearch in Google Scholar
  • 47 Kreukels BP. et al. Electrophysiological correlates of information processing in breast-cancer patients treated with chemotherapy. Breast Cancer Res. Treat 2005; 94: 53-61.
    CrossrefPubMedSearch in Google Scholar