J Neurol Surg B Skull Base 2018; 79(S 01): S1-S188
DOI: 10.1055/s-0038-1633536
Oral Presentations
Georg Thieme Verlag KG Stuttgart · New York

Bone Metabolic Markers in the Clinical Assessment of Patients with Superior Semicircular Canal Dehiscence Treated with Middle Fossa Craniotomy

Thien P. Nguyen
1   University of California Los Angeles, Los Angeles, California, United States
,
Carlito Lagman
1   University of California Los Angeles, Los Angeles, California, United States
,
John P. Sheppard
1   University of California Los Angeles, Los Angeles, California, United States
,
Courtney Duong
1   University of California Los Angeles, Los Angeles, California, United States
,
Vera Ong
1   University of California Los Angeles, Los Angeles, California, United States
,
Yasmeen Alkhalid
2   Medical College of Georgia, Augusta, Georgia, United States
,
Prasanth Romiyo
3   Cooper Medical School of Rowan University, Camden, New Jersey, United States
,
Daniel Azzam
4   University of California Irvine, Irvine, California, United States
,
Giyarpuram Prashant
1   University of California Los Angeles, Los Angeles, California, United States
,
Quinton Gopen
1   University of California Los Angeles, Los Angeles, California, United States
,
Isaac Yang
1   University of California Los Angeles, Los Angeles, California, United States
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
02. Februar 2018 (online)

Auch verfügbar auf
 

Importance The role of bone metabolic markers in the clinical assessment of patients with superior semicircular canal dehiscence (SSCD) has not been elucidated.

Objective To investigate the relationships between levels of serum calcium, 25-hydroxyvitamin D, and thyroid stimulating hormone, and symptoms in adult patients treated with surgical treatment of superior semicircular canal dehiscence through a middle fossa craniotomy.

Design, Setting, and Participants In this retrospective study, the medical records from a single academic medical center in the United States were reviewed to identify adult patients diagnosed with SSCD on high-resolution computed tomography images of the temporal bone and who had undergone surgical repair by the senior authors between March 2011 and May 2017.

Interventions Surgical plugging of the dehiscence through a middle fossa approach.

Main Outcomes and Measures Symptom outcome after surgical repair of SSCD.

Results A total of 99 patients (64 females and 35 males; average age 52 years; 118 surgeries) were included. The level of serum calcium was correlated with bilateral superior semicircular canal dehiscence (rpb = −0.24, p = 0.03) and with the need for a second surgery (rpb = −0.32, p = 0.005). The level of 25-hydroxyvitamin D was correlated with preoperative hyperacusis (rpb = −0.98, p = 0.02) and correlated with postoperative autophony (rpb = 0.96, p = 0.04). The level of thyroid stimulating hormone was correlated with preoperative autophony, amplification, and tinnitus (rpb = −0.71, rpb = −0.75, rpb = −0.70, p < 0.001).

Conclusion and Relevance Bone metabolic markers may be important in the clinical assessment of SSCD patients and could be potential targets for symptom management.