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CC BY-NC-ND 4.0 · Joints 2018; 06(01): 004-009
DOI: 10.1055/s-0038-1636948
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Migration of Mesenchymal Stem Cells of Bursal Tissue after Rotator Cuff Repair in Rats

Elem Safi   *
1   Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany
,
Andreas Ficklscherer   *
1   Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany
,
Maryna Bondarava
1   Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany
,
Oliver Betz
1   Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany
,
Anja Zhang
1   Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany
,
Volkmar Jansson
1   Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany
,
Peter E. Müller
1   Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich, Munich, Germany
› Author Affiliations Funding All the authors report grants from Munich Working Group for sponsorship of orthopaedic and trauma surgery research, during the conduct of the study. This study was funded by the Munich Working Group for sponsorship of orthopaedic and trauma surgery research at the Ludwig-Maximilian-University e.V (Münchner Arbeitsgemeinschaft zur Förderung der Orthopädischen und Unfallchirurgischen Forschung an der LMU e.V [MAOUF], a nonprofit organization) 2014.
Further Information

Publication History

22 October 2017

04 February 2018

Publication Date:
13 March 2018 (online)

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Abstract

Purpose The purpose of this study is to verify migration of mesenchymal stem cells of bursal tissue into the healing site after rotator cuff repair in rats.

Methods Fischer rats and green fluorescent protein (GFP)-transgenic rats were used. Bursal tissue from GFP rats was isolated and transplanted into tendon repair sites in Fischer rats. We examined the histology of the rotator cuff and the proportion of GFP-positive cells in the repaired rotator cuff 1, 3, and 6 weeks after surgery.

Results Cell migration was observed during the third and sixth week after surgery. We also found mesenchymal stem cells and formed bursal cluster patterns in the repaired rotator cuff tendons.

Conclusion Mesenchymal stem cells migrated from bursal tissue and infiltrated the repaired rotator cuff tendons.

Clinical Relevance Mesenchymal stem cells from bursal tissue can contribute to the healing progress of the repaired rotator cuff.

Keywords

bursal tissue - rotator cuff - mesenchymal stem cells - cell migration - rats

* Both the authors contributed equally to this article.


 

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