Endoscopy 2018; 50(04): S145
DOI: 10.1055/s-0038-1637467
ESGE Days 2018 ePosters
Georg Thieme Verlag KG Stuttgart · New York

DIFFERENCE OF EPITHELIAL-MESENCHYMAL TRANSITION BETWEEN ADJACENT-TO-CANCER AND NORMAL TISSUE IN THE PATIENTS WHO UNDERWENT ENDOSCOPIC SUBMUCOSAL DISSECTION FOR EARLY GASTRIC CANCER

SJ Hong
1   SoonChunHyang University School of Medicine, Digestive Disease Center and Research Institute, Department of Internal Medicine, Bucheon, Korea, Republic of
,
HJ Jung
1   SoonChunHyang University School of Medicine, Digestive Disease Center and Research Institute, Department of Internal Medicine, Bucheon, Korea, Republic of
,
SH Kim
1   SoonChunHyang University School of Medicine, Digestive Disease Center and Research Institute, Department of Internal Medicine, Bucheon, Korea, Republic of
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

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Aims:

Epithelial-mesenchymal transition (EMT) is known to be associated with tumor progression, invasion and metastasis in gastric cancer. The process of EMT is associated with the down-regulation of epithelial markers, abnormal translocation of E-cadherin, and aberrant up-regulation of mesenchymal markers. The aim of current study is to investigate the difference of EMT between adjacent-to-cancer and normal tissue in early gastric cancer (EGC), and changes of EMT after endoscopic submucosal dissection (ESD).

Methods:

Tissue samples were obtained prospectively from 19 patients with EGC who underwent ESD. We compared the expression level of alpha-smooth muscle actin (α-SMA), vimentin, E-cadherin, TGF-beta, VEGF using the immunohistochemistry between adjacent-to-cancer and normal tissue. Among the 19 patients, 15 patients had the follow-up evaluation of ESD at 3 months after ESD for EGC.

Results:

Adjacent-to-cancer tissue presented a higher value of α-SMA/vimentin/TGF-beta/VEGF expression compared to normal tissue (P< 0.05), which were significantly reduced after ESD (P< 0.05). There were no significant correlation according to tumor location, initial H. pylori infection and H. pylori eradication therapy.

Conclusions:

These results suggested that expression of EMT mesenchymal markers are significantly increased in adjacent-to-early gastric cancer tissue, which are significantly decreased after ESD.