Role of Lactoferrin in Neonates and Infants: An Update

Paolo Manzoni; Alberto Dall'Agnola; Daniel Tomé; David A. Kaufman; Elena Tavella; Marta Pieretto; Alessandro Messina; Daniele De Luca; Marc Bellaiche; Alexis Mosca; Hugues Piloquet; Umberto Simeoni; Jean-Charles Picaud; Antonio Del Vecchio

doi:10.1055/s-0038-1639359

American Journal of Perinatology, Table of Contents

Am J Perinatol 2018; 35(06): 561-565
DOI: 10.1055/s-0038-1639359

Review Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Role of Lactoferrin in Neonates and Infants: An Update

Paolo Manzoni

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Alberto Dall'Agnola

²Department of Neonatology, Ospedale P. Pederzoli, Verona, Italy

,

Daniel Tomé

³UMR PNCA, AgroParisTech, Institut National de la Recherche Agronomique, Université Paris-Saclay, Paris, France

,

David A. Kaufman

⁴Division of Neonatology, Department of Pediatrics, University of Virginia School of Medicine and Children's Hospital, Charlottesville, Virginia

,

Elena Tavella

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Marta Pieretto

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Alessandro Messina

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Daniele De Luca

⁵Department of Pediatrics and Neonatal Critical Care, “A.Béclère” Medical Centre, South Paris University Hospitals, South Paris-Saclay University, Paris, France

,

Marc Bellaiche

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Alexis Mosca

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Hugues Piloquet

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Umberto Simeoni

¹Neonatology and NICU, S. Anna Hospital, AOU Città della Salute e della Scienza, Torino, Italy

,

Jean-Charles Picaud

⁶Service de Réanimation Néonatale, Université, Hôpital de la Croix Rousse, Lyon, France

,

Antonio Del Vecchio

⁷Department of Women's and Children's Health, ASL Bari, Bari, Italy

› Author Affiliations

Abstract

Lactoferrin is one of the most represented and important bioactive proteins in human and mammal milk. In humans, lactoferrin is responsible for several actions targeting anti-infective, immunological, and gastrointestinal domains in neonates, infants, and young children. Evidence-based data vouch for the ability of supplemented lactoferrin to prevent sepsis and necrotizing enterocolitis in preterm infants and to reduce the burden of morbidity related to gastrointestinal and respiratory pathogens in young children. However, several issues remain pending regarding answers and clarification related to quality control, correct intakes, optimal schedules and schemes of supplementations, interactions with probiotics, and different types of milk and formulas. This review summarizes the current evidence regarding lactoferrin and discusses the areas in need of further guidance prior to the adoption of strategies that include a routine use of lactoferrin in neonates and young children.

Keywords

lactoferrin - neonates - infant - nutrition - infection - sepsis - necrotizing enterocolitis

Full Text

References

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