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Thromb Haemost 1994; 71(01): 110-111
DOI: 10.1055/s-0038-1642392
Review Article
Schattauer GmbH Stuttgart

Effect of Dried Ginger on Human Platelet Function

Andrew B Lumb
The Department of Anaesthetics, Harefield Hospital, Hill End Road, Harefield, Middlesex, UK
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Further Information

Publication History

Received: 22 June 1993

Accepted after revision 09 September 1993

Publication Date:
12 July 2018 (online)

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Summary

Eight healthy male volunteers took part in a randomised double blind study of the effects of 2 g dried ginger or placebo capsules on platelet function. Bleeding time, platelet count, thromboelastography and whole blood platelet aggregometry were performed before, 3 h, and 24 h after the capsules. There were no differences between ginger and placebo in any of the variables measured, It is concluded that the effect of ginger on thromboxane synthetase activity is dose dependent, or only occurs with fresh ginger, and that upto 2 g of dried ginger is unlikely to cause platelet dysfunction when used therapeutically.

 

  • References

  • 1 Grontvcd A, Brask T, Kambskard J, Hcntzer E. Ginger root against sea sickness. A controlled trial on the open sea. Acta Otolaryngol (Stockh) 1988; 105: 45-9
    PubMedGoogle Scholar
  • 2 Fischcr-Rasmusscn W, Kjacr SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Fur J Obstct Gynecol Rcprod Biol 1991; 38: 19-24
    PubMedGoogle Scholar
  • 3 Bone ME, Wilkinson DJ, Young JR, Mc Neil J, Charlton S. Ginger root – A new anticmetic. Idle effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia 1990; 45: 669-71
    CrossrefPubMedGoogle Scholar
  • 4 Phillips S, Ruggicr R, Hutchinson SE. Zingiber officinale (Ginger) – An antiemetic for day-case surgery. Anaesthesia 1993; 48: 715-7
    CrossrefPubMedGoogle Scholar
  • 5 Backon J. Ginger as an anticmetic: possible side effects due to its thromboxane synthetase activity. Anaesthesia 1991; 46: 705-6
    PubMedGoogle Scholar
  • 6 Dorso CR, Levin RI, Eldor A, Jaffc EA, Wckscer BB. Chinese food and platelets. N Engl J Med 1980; 303: 756-7
    PubMedGoogle Scholar
  • 7 Srivastava KC. Effect of onion and ginger consumption on platelet thromboxane production in humans. Prostaglandins Leukot Essent Fatty Acids 1989; 35: 183-5
    CrossrefPubMedGoogle Scholar
  • 8 George JN, Shattil SJ. The clinical importance of acquired abnormalities of platelet function. N Engl J Med 1991; 324: 27-39
    CrossrefPubMedGoogle Scholar
  • 9 Mallctt SV, Cox DJ A. Thromboelastography. Br J Anaesth 1992; 69: 307-13
    CrossrefPubMedGoogle Scholar
  • 10 Riess H, Braun G, Brchm G, Hiller E. Critical evaluation of platelet aggregation in whole human blood. Am J Clin Pathol 1986; 85: 50-6
    CrossrefPubMedGoogle Scholar
  • 11 Srivastava KC. Effect of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study. Prostaglandins Lcukotrienes Med 1984; 13: 227-35
    PubMedGoogle Scholar
  • 12 Srivastava KC. Isolation and effects of some ginger components on platelet aggregation and eicosanoid biosynthesis. Prostaglandins Lcukotrienes Med 1986; 25: 187-98
    PubMedGoogle Scholar
  • 13 Backon J. Ginger in preventing nausea and vomiting in pregnancy: a caveat due to its thromboxane synthetase activity and effect on testosterone binding. Eur J Obstet Gvnecol Reprod Biol 1991; 42: 163-4
    PubMedGoogle Scholar
  • 14 Fulder S. Ginger: The ultimate home remedy. Souvenir Press; London: 1993: 66-70
    Google Scholar
  • 15 Rodgers RP C, Levin J. A critical reappraisal of the bleeding time. Semin Thromb Hemost 1990; 16: 1-20
    Article in Thieme ConnectPubMedGoogle Scholar
  • 16 Gupta NK, Martin PG, Greenstein D, Walker DR. Haemostasis and thromboelastography: A cautious note. Br J Anaesth 1993; 70: 699
    CrossrefPubMedGoogle Scholar