Expression of a Paternal History of Premature Myocardial Infarction on Fibrinogen, Factor VIIC and PAI-1 in European Offspring - The EARS Study

L Bara; V Nicaud; L Tiret; F Cambien; M M Samama; On behalf of the EARS group

doi:10.1055/s-0038-1642456

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1994; 71(04): 434-440
DOI: 10.1055/s-0038-1642456

Review Article

Schattauer GmbH Stuttgart

Expression of a Paternal History of Premature Myocardial Infarction on Fibrinogen, Factor VIIC and PAI-1 in European Offspring - The EARS Study

L Bara

¹The Laboratoire de Thrombose Expérimentale, Paris VI University, Paris, France

,

V Nicaud

²The Institut National de la Santé et de la Recherche Médicale (INSERM) U 258, Paris, France

,

L Tiret

²The Institut National de la Santé et de la Recherche Médicale (INSERM) U 258, Paris, France

,

F Cambien

²The Institut National de la Santé et de la Recherche Médicale (INSERM) U 258, Paris, France

³The INSERM SC7, Paris, France

,

M M Samama

¹The Laboratoire de Thrombose Expérimentale, Paris VI University, Paris, France

,

On behalf of the EARS group

› Author Affiliations

Abstract

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Summary

To assess the role of genetic and environmental factors in the predisposition to atherosclerosis, 682 students whose father had suffered a myocardial infarction before the age of 55 (“cases”) and 1312 controls matched for age and sex, were recruited from 14 Universities in Europe. Fibrinogen, factor Vile and PAI-1 were compared between cases and controls across European regions. Fibrinogen and factor Vile were positively correlated with BMI, smoking and contraception. PAI-1 was positively and independently correlated with BMI and waist-to-hip ratio, and negatively with contraception. Factor Vile and PAI-1 were correlated with cholesterol and triglycerides, and fibrinogen was weakly correlated with LDL-cholesterol. After adjustment for covariates and lipids, fibrinogen level was significantly higher in male cases than in controls (2.38 vs 2.29, p <0.01). No such difference was found in females (2.59 vs 2.57 - NS). There was no significant case/control difference for factor Vile and PAI-1. These results support the hypothesis that fibrinogen is a transmissible risk factor of coronary artery disease in males. No such evidence was provided for factor Vile and PAI-1.

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References

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