Non-Fasting Factor VII Coagulant Activity (FVII:C) Increased by High-Fat Diet

E M Bladbjerg; P Marckmann; B Sandström; J Jespersen

doi:10.1055/s-0038-1642518

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1994; 71(06): 755-758
DOI: 10.1055/s-0038-1642518

Review Article

Schattauer GmbH Stuttgart

Non-Fasting Factor VII Coagulant Activity (FVII:C) Increased by High-Fat Diet

E M Bladbjerg

¹The Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry, Ribe County Hospital in Esbjerg, and Institute for Thrombosis Research, South Jutland University Centre, Esbjerg, Denmark

,

P Marckmann

²The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

,

B Sandström

²The Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark

,

J Jespersen

¹The Section of Coagulation and Fibrinolysis, Department of Clinical Chemistry, Ribe County Hospital in Esbjerg, and Institute for Thrombosis Research, South Jutland University Centre, Esbjerg, Denmark

› Institutsangaben

Abstract

als PDF herunterladen

Summary

Preliminary observations have suggested that non-fasting factor VII coagulant activity (FVII:C) may be related to the dietary fat content. To confirm this, we performed a randomised cross-over study. Seventeen young volunteers were served 2 controlled isoenergetic diets differing in fat content (20% or 50% of energy). The 2 diets were served on 2 consecutive days. Blood samples were collected at 8.00 h, 16.30 h and 19.30 h, and analysed for triglycerides, FVII coagulant activity using human (FVII:C) or bovine thromboplastin (FVII:Bt), and FVII amidolytic activity (FVIPAm). The ratio FVII:Bt/FVII:Am (a measure of FVII activation) increased from fasting levels on both diets, but most markedly on the high-fat diet. In contrast, FVII: Am (a measure of FVII protein) tended to decrease from fasting levels on both diets. FVII:C rose from fasting levels on the high-fat diet, but not on the low-fat diet. The findings suggest that high-fat diets increase non-fasting FVII:C, and consequently may be associated with increased risk of thrombosis.

PDF (336 kb)

Referenzen

References
1 Orlando M, Leri O, Macioce G, Mattia G, Ferri GM. Factor VII in subjects at risk for thromboembolism: Activation or increased synthesis?. Haemostasis 1987; 17: 340-3
2 Hoffman C, Shah A, Sodums M, Hultin MB. Factor VII activity state in coronary artery disease. J Lab Clin Med 1988; 111: 475-81
3 De Sousa JC, Azevedo J, Soria C, Barros F, Ribeiro C, Parreira F, Caen JP. Factor VII hyperactivity in acute myocardial thrombosis. A relation to the coagulation activation. Thromb Res 1988; 51: 165-73
4 Suzuki T, Yamauchi K, Matsushita T, Furumichi T, Furui H, Tsuzuki J, Saito H. Elevation of factor VII activity and mass in coronary artery disease of varying severity. Clin Cardiol 1991; 14: 731-6
5 Meade TW, North WRS. Population-based distributions of haemostatic variables. Br Med Bull 1977; 33: 283-8
6 Meade TW, Chakrabarti R, Haines AP, North WRS, Stirling Y, Thompson SG. Haemostatic function and cardiovascular death: Early results of a prospective study. Lancet 1980; i: 1050-3
7 Meade TW, Brozovic M, Chakrabarti R, Haines AP, Imeson JD, Mellows S, Miller GJ, North WRS, Stirling Y, Thompson SG. Haemostatic function and ischaemic heart disease: Principal results of The Northwick Park Heart Study. Lancet 1986; ii: 533-7
8 Miller GJ, Martin JC, Webster J, Wilkes H, Miller NE, Wilkinson WH, Meade TW. Association between dietary fat intake and plasma factor VII coagulant activity – A predictor of cardiovascular mortality. Atherosclerosis 1986; 60: 269-77
9 Marckmann P, Sandstrom B, Jespersen J. Dietary effects on circadian fluctuations in human blood coagulation factor VII and fibrinolysis. Atherosclerosis 1993; 101: 225-34
10 Miller GJ, Martin JC, Mitropoulos KA, Reeves BEA, Thompsom RL, Meade TW, Cooper JA, Cruickshank JK. Plasma factor VII is activated by postprandial triglyceridaemia irrespective of dietary fat composition. Atherosclerosis 1991; 86: 163-71
11 Balleisen L, Bailey J, Epping PH, Schulte H, Van de Loo J. Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population: I. Baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill-using, and menopause. Thromb Haemost 1985; 54 (02) 475-9
12 Estimates of energy and protein requirements of adults and children. In: FAO/WHO/UNU Expert Consultation. Energy and Protein Requirements. Geneva: World Health Organization; 1985: 71-8
13 Poller L, Thomson J. The Manchester comparative reagent. A national reference standard for anticoagulant therapy. In: Human blood coagulation. Chapter III: Laboratory methods. Hemker HC, Loeliger EA, Veltkamp JJ. (eds) Leiden: University Press; 1969: 290-5
14 Kitchen S, Malia RG, Preston FE. A comparison of methods for the measurement of activated factor VII. Thromb Haemost 1992; 68 (03) 301-5
15 Miller GJ, Walter SJ, Stirling Y, Thompson SG, Esnouf MP, Meade TW. Assay of factor VII activity by two techniques: evidence for increased conversion of VII to Vila in hyperlipidaemia, with possible implications for ischaemic heart disease. Br J Haematol 1985; 59: 249-58
16 Mitropoulos KA, Martin JC, Reeves BEA, Esnouf MP. The activation of the contact phase of coagulation by physiologic surfaces in plasma: the effect of large negatively charged liposomal vesicles. Blood 1989; 73: 1525-33
17 Mitropoulos KA, Miller GJ, Watts GF, Durrington PN. Lipolysis of triglyceride-rich lipoproteins activates coagulant factor XII: a study in familial lipoprotein-lipase deficiency. Atherosclerosis 1992; 95: 119-25
18 De Sousa JC, Bruckert E, Giral P, Soria C, Chapman J, Truffert J, Dairou F, De Gennes JL, Caen JP. Coagulation factor VII and plasma triglycerides. Haemostasis 1989; 19: 125-30
19 De Sousa JC, Bruckert E, Giral P, Soria C, Truffert J, Mirshahi MC, De Gennes JL, Caen JP. Plasma factor VII, triglyceride concentration and fibrin degradation products in primary hyperlipidaemia: A clinical and laboratory study. Haemostasis 1989; 19: 83-90
20 Dalaker K, Smith P, Arnesen H, Prydz H. Factor VH-phospholipid complex in male survivors of acute myocardial infarction. Acta Med Scand 1987; 222: 111-6
21 Marckmann P, Sandstrom B, Jespersen J. The variability of and association between measures of blood coagulation, fibrinolysis and blood lipids. Atherosclerosis 1992; 96: 235-44
22 Marckmann P, Sandstrom B, Jespersen J. Effects of total fat content and fatty acid composition on factor VII coagulant activity and blood lipids. Atherosclerosis 1990; 80: 227-33
23 Marckmann P, Sandstrom B, Jespersen J. Fasting blood coagulation and fibrinolysis of young adults unchanged by reduction in dietary fat content. Arterioscler Thromb 1992; 12: 201-5
24 Hansen JB, Olsen JO, Wilsgård L, Østerud B. Effects of dietary supplementation with cod liver oil on monocyte thromboplastin synthesis, coagulation and fibrinolysis. J Intern Med 1989; 225 Suppl (01) 133-9