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Thromb Haemost 1988; 59(02): 264-268
DOI: 10.1055/s-0038-1642767
Original Articles
Schattauer GmbH Stuttgart

Cytomegalovirus Alters the von Willebrand Factor Content in Human Endothelial Cells

C A Bruggeman
1   The Dept. of Medical Microbiology, University of Limburg, Maastricht, The Netherlands
,
W H M Debie
1   The Dept. of Medical Microbiology, University of Limburg, Maastricht, The Netherlands
,
A D Muller
2   The Dept, of Biochemistry, University of Limburg, Maastricht, The Netherlands
,
B Schutte
3   The Dept, of Internal Medicine, University of Limburg, Maastricht, The Netherlands
,
M CE van Dam-Mieras
4   The Open University, Heerlen, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 07 May 1987

Accepted after revision 10 December 1987

Publication Date:
21 May 2018 (online)

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Summary

Cultured human endothelial cells were infected with human cytomegalovirus AD 169 and Kerr. The infection resulted in the appearance of viral antigens in the nuclei of about 10% of the endothelial cells and in the concomittant disappearance of vWF from the infected cells. No differences were observed between endothelial cells from different sources (umbilical cord veins or arteries, adult veins).

Keywords

von - Willebrand factor - Cytomegalovirus - Endothelial cells
 

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