SHORT-TERM LYSIS BY ULTRAHIGH STREPTOKINASE TREATMENT IN CHRONIC ARTERIAL OCCLUSIONS AND ACUTE DEEP VENOUS THROMBOSIS

171 chronic arterial occlusions and 86 acute venous thromboses were treated by systemic ultrahigh streptokinase (UHSK) infusions. 38% of the patients were over 65, 27% over 70 years of age. The UHSK scheme consisted of a 1.5 million units SK per hour maintenance infusion over a period of 6 hours. 46% of the patients received one, 47% two, 6% three, and 1% four series (one series per day). 81% of the arterial patients had a history of less than 3 months. In 54% of the cases PTA followed UHSK treatment for dilation of a residual stenosis or removal of occlusion residues still persistent. In the venous patients the most proximal location was distributed as follows: calf veins 1%, femoral vein 57%, iliac vein 28%, subclavian vein 14%. The average thrombosis history was 8 days.

Clearance rates of chronic arterial occlusions

By setting up of sub-groups more favorable results were calculated. For exemple, a femoral occlusion group consisting of cases with a history shorter than 6 weeks and 2 or 3 calf arteries patent displayed a clearance rate of 77%, a figure much higher than the overall femoral result

Clearance rates of deep venous thrombosis

The thrombosis duration played a significant role for thrombosis dissolution. The average occlusion history was 6 days in the total clearance group compared with 12 days in the unsuccessful cohort.