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Thromb Haemost 1990; 63(03): 331-335
DOI: 10.1055/s-0038-1645041
Review Article
Schattauer GmbH Stuttgart

Lp(a): An Interloper into the Fibrinolytic System?

Lindsey A Miles
The Committee on Vascular Biology, Research Institute of Scripps Clinic, La Jolla, California, USA
,
Edward F Plow
The Committee on Vascular Biology, Research Institute of Scripps Clinic, La Jolla, California, USA
› Author Affiliations
Further Information

Publication History

Received 29 November 1989

Accepted after revision 06 March 1990

Publication Date:
30 June 2018 (online)

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  • References

  • 1 Berg K. A new scrum type system in man - the Lp system. Acta Fathol Microbiol Scand 1963; 59: 369-82
    PubMedSearch in Google Scholar
  • 2 Armstrong VW, Cremer P, Eberle E, Manke A, Shuzle F, Wieland H, Seidel D. The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis. Atherosclerosis 1986; 62: 249-57
    CrossrefPubMedSearch in Google Scholar
  • 3 Dahlen G, Guyton JR, Attar M, Farmer JA, Kautz JA, Gotto Jr AM. Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. Circulation 1974; 74: 758-65
    PubMedSearch in Google Scholar
  • 4 Eaton DL, Fless GM, Kohr WJ, McLean JW, Xu Q-T, Miller CG, Lawn RM, Scanu AM. Partial amino acid sequence of apolipopro-tein(a) shows that it is homologous to plasminogen. Proc Natl Acad Sci USA 1987; 84: 3224-8
    CrossrefPubMedSearch in Google Scholar
  • 5 McLean JW, Tomlinson JE, Kuang W-J, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM. cDNA sequence of human apolipopro-tein(a) is homologous to plasminogen. Nature 1987; 330: 132-7
    CrossrefPubMedSearch in Google Scholar
  • 6 Schwartz CJ, Valente AJ, Kelley JL, Sprague EA, Edwards EH. Thrombosis and the development of atherosclerosis: Rokitansky revisited. Semin Thromb Hemostas 1988; 14: 189-95
    Thieme ConnectPubMedSearch in Google Scholar
  • 7 Davies MJ, Thomas AC. Plaque fissuring: The cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J 1985; 53: 363
    CrossrefPubMedSearch in Google Scholar
  • 8 Brown MS, Goldstein JL. Teaching old dogmas new tricks. Nature 1987; 330: 113-4
    CrossrefPubMedSearch in Google Scholar
  • 9 Albers JJ. The measurement of Lp(a) and its clinical application. In: Lipoprotein(a) Scanu AM. (ed) Academic Press; New York: 1989. in press
  • 10 Utermann G. The mysteries of lipoprotein(a). Science 1989; 246: 904-10
    CrossrefPubMedSearch in Google Scholar
  • 11 Dahlen G, Berg K, Gillnas T, Ericson C. Lp(a) lipoprotein/pre-Bl-lipoprotein in Swedish middle-aged males and in patients with coronary heart disease. J Clin Genet 1975; 7: 334-41
    PubMedSearch in Google Scholar
  • 12 Wottawa A, Fromme K, Klein G. Lipoprotein (a) bei koronarer Herzkrankheit und Myokardinfarkt. Münch Med Wschr 1984; 126: 53-5
    PubMedSearch in Google Scholar
  • 13 Hoff HF, Beck GJ, Skibinski MS, Jurgens G, O’Neill J, Kramer J, Lytle B. Serum Lp(a) level as a predictor of vein graft stenosis after coronary artery bypass surgery in patients. Circulation 1988; 1238-44
    PubMedSearch in Google Scholar
  • 14 Diekstall F, Canzler H, Shmidt E, Demeler U. Lipoprotein(a) bei artericllcn retinalen Gefäßverschlüssen. Ophthalmologie 1987; 84: 369-71
    PubMedSearch in Google Scholar
  • 15 Zenker G, Koltringer P, Bone G, Niederkorn K, Pfeiffer K, Jurgens G. Lipoprotein(a) as a strong indicator for cerebrovascular disease. Stroke 1986; 17: 942-5
    CrossrefPubMedSearch in Google Scholar
  • 16 Scanu AM. Lipoprotein(a): A genetically determined lipoprotein containing a glycoprotein of the plasminogen family. Semin Thromb Hemostas 1988; 14: 266-70
    Thieme ConnectPubMedSearch in Google Scholar
  • 17 Menzel HJ, Dieplinger H, Lackner C, Hoppichler F, Lloyd JK, Muller DR, Labeur C, Talmud PJ, Utermann G. Abetalipoprotein-emia with an ApoB-100-lipoprotein(a) glycoprotein complex in plasma. Indication for an assembly defect. J Biol Chem 1990; 265: 981-6
    PubMedSearch in Google Scholar
  • 18 Jurgens G, Marth E, Kostner GM, Holasek A. Investigation of the Lp(a) Lipoprotein: lipoprotein aggregating and enzymatic activity associated with the Lp(a) polypeptide. Artery 1977; 31: 13-26
    PubMedSearch in Google Scholar
  • 19 Salonen E-M, Jauhiainen M, Zardi L, Vaheri A, Ehnholm C. Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it. EMBO J 1989; 8: 4035-40
    PubMedSearch in Google Scholar
  • 20 Koschinsky ML, Beisiegel U, Henne-Bruns D, Eaton DL, Lawn RM. Apolipoprotein(a) size heterogeneity is related to variable number of repeat sequences in its mRNA. Biochemistry 1990; 29: 640-4
    CrossrefPubMedSearch in Google Scholar
  • 21 Trexler M, Vali Z, Patthy L. Structure of the omega-aminocarboxylic acid-binding sites of human plasminogen. Arginine 70 and aspartic acid 56 are essential for binding of ligand by kringle 4. J Biol Chem 1982; 257: 7401-6
    PubMedSearch in Google Scholar
  • 22 Hochschwender SM, Laursen RA. The lysine binding sites of human plasminogen. Evidence for a critical tryptophan in the binding site of kringle 4. J Biol Chem 1981; 256: 11172-6
    PubMedSearch in Google Scholar
  • 23 Lerch PG, Rickli EE. Studies on the chemical nature of lysine-binding sites and on their localization in human plasminogen. Biochim Biophys Acta 1980; 625: 374-8
    CrossrefPubMedSearch in Google Scholar
  • 24 Ramesh V, Petros AM, Llinas M, Tulinsky A, Park CH. Proton magnetic resonance study of lysine-binding to the kringle 4 domain of human plasminogen. J Mol Biol 1987; 198: 481-98
    CrossrefPubMedSearch in Google Scholar
  • 25 Lucas MA, Fretto LJ, McKee PA. The binding of human plasminogen to fibrin and fibrinogen. J Biol Chem 1983; 258: 4249-56
    PubMedSearch in Google Scholar
  • 26 Thorsen S, Clemmensen I, Sottrup-Jensen L, Magnusson S. Adsorption to fibrin of native fragments of known primary structure from human plasminogen. Biochim Biophys Acta 1981; 666: 377-87
    PubMedSearch in Google Scholar
  • 27 Loscalzo J, Fless GM, Scanu A. Lipoprotein (a) inhibits fibrin-dependent enhancement of tissue plasminogen activator activity. Blood 1988; 72 (Suppl. 01) 370a
    PubMedSearch in Google Scholar
  • 28 Harpel PC, Gordon BR, Parker TS. Plasmin catalyzes binding of lipoprotein(a) to immobilized fibrinogen and fibrin. Proc Natl Acad Sci USA 1989; 86: 3847-51
    CrossrefPubMedSearch in Google Scholar
  • 29 Kluft C, Jie AF H, Los P, deWit E, Havekes L. Functional analogy between lipoprotein(a) and plasminogen in the binding to the kringle 4 binding protein, tetranectin. Biochem Biophys Res Commun 1989; 161: 427-33
    CrossrefPubMedSearch in Google Scholar
  • 30 Eaton D, Tomlinson J. Does Lp(a) alter fibrinolysis?. Circulation 1989; 80 (Suppl. 02) 467
    PubMedSearch in Google Scholar
  • 31 Edelberg JM, Gonzalez-Gronow M, Pizzo SV. Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator. Thromb Res 1990; 57: 155-62
    CrossrefPubMedSearch in Google Scholar
  • 32 Karadi I, Kostner GM, Gries A, Nimpf J, Romics L, Malle E. Lipoprotein(a) and plasminogen are immunochemically related. Biochim Biophys Acta 1988; 960: 91-7
    CrossrefPubMedSearch in Google Scholar
  • 33 Edelberg JM, Gonzalez-Gronow M, Pizzo SV. Lipoprotein a inhibits streptokinase-mediated activation of human plasminogen. Biochemistry 1989; 28: 2370-4
    CrossrefPubMedSearch in Google Scholar
  • 34 Gonzalez-Gronow M. Further characterization of the cellular plasminogen binding site: evidence that plasminogen 2 and lipoprotein a compete for the same site. Biochemistry 1989; 28: 2374-7
    CrossrefPubMedSearch in Google Scholar
  • 35 Miles LA, Fless GM, Levin EG, Scanu AM, Plow EF. A potential basis for the thrombotic risks associated with lipoprotein(a). Nature 1989; 339: 301-3
    CrossrefPubMedSearch in Google Scholar
  • 36 Hajjar KA, Gavish D, Breslow JL, Nachman RL. Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature 1989; 339: 303-5
    CrossrefPubMedSearch in Google Scholar
  • 37 Walton KW, Hitchens J, Magnani HN, Khan M. A study of methods of identification and estimation of Lp(a) lipoprotein and of its significance in health, hyperlipidaemia and atherosclerosis. Atherosclerosis 1974; 20: 323-46
    CrossrefPubMedSearch in Google Scholar
  • 38 Clemmensen I, Petersen LC, Kluft C. Purification and characterization of a novel, oligomeric, plasminogen kringle 4 binding protein from human plasma: tetranectin. Eur J Biochem 1986; 156: 327-33
    CrossrefPubMedSearch in Google Scholar
  • 39 Silverstein RL, Nachman RL. Thrombospondin-plasminogen interactions: Modulation of plasmin generation. Semin Thromb Hemostas 1987; 13: 335-42
    Thieme ConnectPubMedSearch in Google Scholar
  • 40 DePoli P, Bacon-Baguley T, Kendra-Franczak S, Cederholm MT, Walz DA. Thrombospondin interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen. Blood 1989; 73: 976-82
    PubMedSearch in Google Scholar
  • 41 Brandstrom A, Dahlen GH, Ranby M. Lipoprotein(a): in vitro effects on tPA mediated fibrinolysis. In: Lipoprotein(a) Academic Press; New York: 1989. in press