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Thromb Haemost 1990; 63(01): 001-005
DOI: 10.1055/s-0038-1645675
Original Article
Schattauer GmbH Stuttgart

Dose-Response Studies on the Effect of n-3 Polyunsaturated Fatty Acids on Lipids and Haemostasis

E Berg Schmidt
The Departments of Clinical Chemistry and Clinical Immunology, Aalborg Hospital, Aalborg, Denmark
,
K Varming
The Departments of Clinical Chemistry and Clinical Immunology, Aalborg Hospital, Aalborg, Denmark
,
E Ernst
The Departments of Clinical Chemistry and Clinical Immunology, Aalborg Hospital, Aalborg, Denmark
,
P Madsen
The Departments of Clinical Chemistry and Clinical Immunology, Aalborg Hospital, Aalborg, Denmark
,
J Dyerberg
The Departments of Clinical Chemistry and Clinical Immunology, Aalborg Hospital, Aalborg, Denmark
› Author Affiliations
Further Information

Publication History

Received 30 May 1989

Accepted after revision 04 October 1989

Publication Date:
02 July 2018 (online)

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Summary

We have studied the dose-response effects of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA’s) on lipids and haemostasis. Ten healthy males were each given 1.3 g,4 g or 9 g of n-3 PUFA’s daily for 6-week periods. Bleeding time, HDL-cholesterol and plasminogen activator inhibitor increased with the dose of n-3 PUFA. Plasma fibrinogen and triglyceride levels were reduced in a dose-dependent fashion.

After ingestion of 1.3 g of n-3 PUFA’s plasma fibrinogen decreased from 9 to 7 μmol/l and HDL-cholesterol increased from 1.2 to 1.3 mmol/l. The bleeding time was prolonged from 5 to 6.5 min while triglyceride levels decreased from 1.2 to 0.9 mmol/l after ingestion of 4 g of n-3 PUFA’s. Dietary supplementation with the highest daily dose (9 g) reduced plasma levels of triglycerides, fibrinogen and von Willebrand factor, while bleeding time, plasminogen activator antigen, plasminogen activator inhibitor and the ratio of HDL-cholesterol to total cholesterol increased.

Keywords

n-3 fatty acids - Fish oil - Dose-response - Lipids - Haemostasis
 

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