Thromb Haemost 1987; 58(02): 679-681 DOI: 10.1055/s-0038-1645954
Schattauer GmbH Stuttgart
Lupus-Like Anticoagulants, Modulation of the Protein C Pathway and Thrombosis
Jean-Marie Freyssinet
INSERM U.311, Bioiogie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomatériaux, Centre Régional de Transfusion Sanguine, Strasbourg, France
,
Jean-Pierre Cazenave
INSERM U.311, Bioiogie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomatériaux, Centre Régional de Transfusion Sanguine, Strasbourg, France
› Author Affiliations
Key words Lupus-like anticoagulants - Thrombosis - Phospholipids - Protein C pathway - Thrombogenic endothelium
References
1
Shapiro SS,
Thiagarajan P.
Lupus anticoagulants. Prog Hemostasis Thromb 1982; 6: 263-285
2
Feinstein DI,
Rapaport SI.
Acquired inhibitors of blood coagulation. Prog Hemostasis Thromb 1972; 1: 75-95
3
Conley CL,
Hartmann RC.
A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Clin Invest 1952; 31: 621-622
4
Schleider MA,
Nachman RL,
Jaffe EA,
Coleman M.
A clinical study of the lupus anticoagulant. Blood 1976; 48: 499-509
5
Cohen AJ,
Philipps TM,
Kessler CM.
Circulating coagulation inhibitors in the acquired immunodeficiency syndrome. Ann Intern Med 1986; 104: 175-180
6
Gastineau DA,
Kazmier FJ,
Nichols WL,
Bowie E JW.
Lupus anticoagulant: an analysis of the clinical and laboratory features of 219 cases. Amer J Hematol 1985; 19: 265-275
7
Lechner K,
Pabinger-Fashing I.
Lupus anticoagulants and thrombosis. Haemostasis 1985; 15: 254-262
8
Hougie C.
Circulating anticoagulants. In: Recent Advances in Blood Coagulation.
Poller L.
(Ed) Churchill Livingstone. Edinburgh: 1985 4. 63-90
9
Vermylen J,
Blockmans D,
Spitz B,
Deckmyn H.
Thrombosis and immune disorders. Clin Haematol 1986; 15: 393-412
10
Elias M,
Eldor A.
Thromboembolism in patients with the “lupus”-type circulating anticoagulant. Ann Intern Med 1984; 144: 510-515
11
Zwaal R FA,
Hemker HC.
Blood cell membranes and haemostasis. Haemostasis 1982; 11: 12-39
12
Thiagarajan P,
Shapiro SS,
De Marco L.
Monoclonal immunoglobulin MX, coagulation inhibitor with phospholipid specificity. Mechanism of a lupus anticoagulant. J Clin Invest 1980; 66: 397-405
13
Howard MA,
Firkin BG.
Investigations of the lupus-like inhibitor by-passing activity of platelets. Thromb Haemostas 1983; 50: 775-779
14
Dahlback B,
Nilsson IM,
Frohm B.
Inhibition of platelet prothrombinase activity by a lupus anticoagulant. Blood 1983; 62: 218-225
15
Kelsey PR,
Stevenson KJ,
Poller L.
The diagnosis of lupus anticoagulants by the activated partial thromboplastin time. The central role of phosphatidylserine. Thromb Haemostas 1984; 52: 172-175
16
Triplett DA,
Brandt JT,
Mass RL.
The laboratory heterogeneity of lupus anticoagulants. Arch Pathol Lab Med 1985; 109: 946-951
17
Rauch J,
Tannenbaum M,
Tannenbaum H,
Ramelson H,
Cullis PR,
Tilcock CP S,
Hope MJ,
Janoff AS.
Human hybridoma lupus anticoagulants distinguish between lamellar and hexagonal phase lipid systems. J Biol Chern 1986; 261: 9672-9677
18
Alving CR.
Antibodies to liposomes, phospholipids and phosphate esters. Chem Phys Lipids 1986; 40: 303-314
19
Harris EN,
Gharavi EA,
Boey ML,
Patel BM,
Mackworth-Young CG,
Loizou S,
Hughes G VR.
Anticardiolipin antibodies: Detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983; II: 1211-1214
20
Lockshin MD,
Druzin ML,
Goei S,
Qamar T,
Magid MS,
Jovanovic L,
Ferenc M.
Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med 1985; 313: 152-156
21
Hamsten A,
Norberg R,
Bjorkholm M,
De Faire U,
Holm G.
Antibodies to cardiolipin in young survivors of myocardial infarction: An association with recurrent cardiovascular events. Lancet 1986; I: 113-116
22
Alberts B,
Bray D,
Lewis J,
Raff M,
Roberts K,
Watson JD.
In: Molecular Biology of the Cell. Garland Publishing; New York: 1983
23
Vaarala O,
Palosuo T,
Kleemola M,
Aho K.
Anticardiolipin response in acute infections. Clin Immunol Immunopathol 1986; 41: 8-15
24
Carreras LO,
Defreyn G,
Machin SJ,
Vermylen J,
Deman R,
Spitz B,
Van Assche A.
Arterial thrombosis, intrauterine death and “lupus” anticoagulant: Detection of immunoglobulin interfering with prostacyclin production. Lancet 1981; 1: 244-246
25
Angles-Cano E,
Sultan Y,
Clauvel JP.
Predisposing factors to thrombosis in systemic lupus erythematosus. J Lab Clin Med 1979; 94: 312-323
26
Esmon CT.
Regulation of protein C activation by components of the endothelial cell surface. In: Vascular endothelium in hemostasis and thrombosis.
Gimbrone MA.
(Ed). Churchill Livingstone; Edinburgh: 1986. p 99-119
27
Stenflo J.
Structure and function of protein C. Semin Thromb Hemostasis 1984; 10: 109-121
28
Walker FJ.
Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation. J Biol Chem 1981; 256: 11128-11131
29
Griffin JH.
Clinical studies of protein C. Semin Thromb Hemostasis 1984; 10: 162-166
30
Comp PC,
Esmon CT.
Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med 1984; 311: 1525-1528
31
Comp PC,
DeBault LE,
Esmon NL,
Esmon CT.
Human thrombomodulin is inhibited by IgG from two patients with non-specific anticoagulants. Blood 1983; 62 5 Suppl 1 299a (Abstr)
32
Cariou R,
Tobelem G,
Caen J.
L’anticoagulant circulant de type lupus, facteur de risque thrombotique par inhibition de 1’activation de la proteine C. C R Acad Sci Ser III-Vie 1986; 303: 113-118
33
Freyssinet JM,
Gauchy J,
Cazenave JP.
The effect of phospholipids on the activation of protein C by the human thrombin-thrombomodulin complex. Biochem J 1986; 238: 151-157
34
Galvin JB,
Kurosawa S,
Moore K,
Esmon CT,
Esmon NL.
Reconstitution of rabbit thrombomodulin into phospholipid vesicles. J Biol Chem 1987; 262: 2199-2205
35
Freyssinet JM,
Wiesel ML,
Gauchy J,
Boneu B,
Cazenave JP.
An IgM lupus anticoagulant that neutralizes the enhancing effect of phospholipid on purified endothelial thrombomodulin activity. A mechanism for thrombosis. Thromb Haemostas 1986; 55: 309-313
36
Friedman KD,
Marlar RA,
Gill JC,
Endres-Brooks J,
Montgomery RR.
Protein S deficiency in patients with the lupus anticoagulant. Blood 1986; 68 5 Suppl 1 333 (Abstr)
37
Maruyama I,
Majerus PW.
The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 cancer cells. J Biol Chem 198 260: 15432-15438
38
Sakata Y,
Curriden S,
Lawrence D,
Griffin JH,
Loskutoff DJ.
Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases anti-activator activity. Proc Natl Acad Sci USA; 1985; 82: 1121-1125
39
Van Hinsberg V WM,
Bertina RM,
Van Wijngaarden A,
Van Tilburg NH,
Emeis JJ,
Haverkate F.
Activated protein C decreases plasminogen activator-inhibitor activity in endothelial cell-conditioned medium. Blood 1985; 65: 444-451
40
Cazenave JP,
Klein-Soyer C,
Beretz A.
The vascular endothelium. An important site of blood-tissue exchanges. Inter Angiol 1984; 3: 27-32
41
Nawroth PP,
Stern DM.
Endothelial cells as active participants in procoagulant reactions. In: Vascular endothelium in hemostasis and thrombosis.
Gimbrone MA.
(Ed) Churchill Livingstone; Edinburgh: 1986. p 14-39
42
Moore KL,
Andreoli SP,
Esmon NL,
Esmon CT,
Bang NU.
Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 1987; 79: 124-130
43
Nawroth PP,
Bank I,
Handley D,
Cassimeris J,
Chess L,
Stern D.
Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1. J Exp Med 1986; 163: 1363-1375
44
Nawroth PP,
Handley DA,
Esmon CT,
Stern DM.
Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci USA 1986; 83: 3460-3464
45
Nawroth PP,
Stern DM.
Modulation of endothelial cell hemostatic properties by tumor necrosis factor. J Exp Med 1986; 163: 740-745
46
Nawroth PP,
Cornelson S,
Stern DM.
Tumor necrosis factor upregulates factor IX/IXa binding sites and factor IXa-VIII-mediated factor Xa formation on endothelium. Circulation 1986; 74: 11-233 (Abstr)
47
Nawroth PP,
Handley DA,
Stern DM.
Tumor necrosis factor-induced tumor killing involves coagulation. Circulation 1986; 11-233 (Abstr)