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Thromb Haemost 1987; 58(02): 718-723
DOI: 10.1055/s-0038-1645961
Original Article
Schattauer GmbH Stuttgart

Platelet Deposition at Angioplasty Sites and Platelet Survival Time After PTA in lliac and Femoral Arteries: Investigations with Indium-111-Oxine Labelled Platelets in Patients with ASA (1.0 g/Day)-Therapy

E Minar
The Department of Angiology (Head: Prof. Dr. H. Ehringer), I. Medical University Clinic (Head: Prof. Dr. Dr. h. c. E. Deutsch), Vienna, Austria
,
H Ehringer
The Department of Angiology (Head: Prof. Dr. H. Ehringer), I. Medical University Clinic (Head: Prof. Dr. Dr. h. c. E. Deutsch), Vienna, Austria
,
R Ahmadi
The Department of Angiology (Head: Prof. Dr. H. Ehringer), I. Medical University Clinic (Head: Prof. Dr. Dr. h. c. E. Deutsch), Vienna, Austria
,
R Dudczak
The Department of Angiology (Head: Prof. Dr. H. Ehringer), I. Medical University Clinic (Head: Prof. Dr. Dr. h. c. E. Deutsch), Vienna, Austria
,
G Porenta
The Department of Angiology (Head: Prof. Dr. H. Ehringer), I. Medical University Clinic (Head: Prof. Dr. Dr. h. c. E. Deutsch), Vienna, Austria
› Author Affiliations
Further Information

Publication History

Received 17 November 1986

Accepted after revision 26 March 1987

Publication Date:
27 June 2018 (online)

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Summary

In this study we have assessed the deposition of 111-In-oxine-labelled platelets - using a dual radiotracer method - at angioplasty sites of the lower extremities in 20 patients (14 male, 6 female; median age: 60 years) with ASA (1.0 g/day)-therapy. The platelet survival time (PST) - using the multiple hit model -was evaluated before and after percutaneous transluminal angio-plasry, and we also measured the plasma levels of β-thrombo-globulin (β TG) and platelet fuetui 4 (PF 4) before and after PTA.

Before PTA, scintigraphy was positive in only one patient, while 24 hours after PTA a positive scintigraphic result was observed in 16/20 patients. The median target/non target-ratio was 1.0 (0.66-1.3) before PTA, and this ratio increased significantly (p <0.0005) to 1.53 (1.0-3.3) after PTA.

The median PST decreased significantly (185.0 hours before PTA → 145.2 hours after PTA; p <0.001), while the median platelet turnover increased from 34,000/μl/day to 47,900/μl/day(p<0.01).

The median plasma levels of the platelet specific proteins increased significantly immediately after PTA (p <0.001), but one day later they were not significantly different from the pretreatment values.

The quantitative methods used in this study seem a valuable tool to evaluate the effects of different therapeutical - especially antiplatelet - interventions after PTA in humans, thus helping to find the best antithrombotic regimen for this widely used therapeutical procedure.

Keywords

Transluminal angioplasty - Platelet scintigraphy - Platelet survival time - Acetylsalicylic acid
 

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