Possible Role of Fibrinogen in the Aggregation of White Blood Cells

S Berliner; J Fuchs; U Seligsohn; N Kariv; B Hazaz; Z Rotenberg; I Weinberger; J Agmon; J Pinkhas; M Aronson

doi:10.1055/s-0038-1645963

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1987; 58(02): 749-752
DOI: 10.1055/s-0038-1645963

Original Article

Schattauer GmbH Stuttgart

Possible Role of Fibrinogen in the Aggregation of White Blood Cells

Authors

S Berliner

¹The Department of Internal Medicine “D” at the Beilinson Medical Center, Petach Tikva, Israel
J Fuchs

²The Department of Internal Medicine “A” at the Beilinson Medical Center, Petach Tikva, Israel
U Seligsohn

³The Institute of Hematology at the Tel Aviv Medical Center, Tel Aviv, Israel
N Kariv

⁴The Department for Cell Biology at the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
B Hazaz

¹The Department of Internal Medicine “D” at the Beilinson Medical Center, Petach Tikva, Israel
Z Rotenberg

²The Department of Internal Medicine “A” at the Beilinson Medical Center, Petach Tikva, Israel
I Weinberger

²The Department of Internal Medicine “A” at the Beilinson Medical Center, Petach Tikva, Israel
J Agmon

²The Department of Internal Medicine “A” at the Beilinson Medical Center, Petach Tikva, Israel
J Pinkhas

¹The Department of Internal Medicine “D” at the Beilinson Medical Center, Petach Tikva, Israel
M Aronson

⁴The Department for Cell Biology at the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Abstract

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Summary

In order to verify whether leukocyte aggregation correlated with aggregation of other cellular elements during inflammation, we examined the state of leukocyte adhesiveness/aggregation (LAA) in the peripheral blood and red cell aggregation. Correlation was found to be significant as was the correlation between LA A and fibrinogen, and with the fibrin/fibrinogen degradation products concentration during various inflammatory states. In vitro leukocyte aggregation was decreased when the cells were suspended in autologous heat defibrinogenated plasma as compared to cells suspended in autologous native plasma. Heat aggregated fibrinogen but not native fibrinogen caused leukocyte aggregation in vitro. Finally, Arvin defibrinogenation in rabbits reduced the state of LAA in endotoxinemic rabbits. Integrating all this information, we assume that fibrinogen participates not only in the aggregation phenomena of red cells and platelets, but also in those of leukocytes.

Keywords

Fibrinogen - Leukocyte aggregation

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References

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