Hypothyroidism Leads to More Small-Sized Platelets in Circulation

J J van Doormaal; J van der Meer; H R Oosten; M R Halie; H Doorenbos

doi:10.1055/s-0038-1646037

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1987; 58(04): 964-965
DOI: 10.1055/s-0038-1646037

Original Article

Schattauer GmbH Stuttgart

Hypothyroidism Leads to More Small-Sized Platelets in Circulation

J J van Doormaal

^*The Division of Clinical Endocrinology, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands

,

J van der Meer

^**The Division of Haematology, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands

,

H R Oosten

^*The Division of Clinical Endocrinology, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands

,

M R Halie

^**The Division of Haematology, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands

,

H Doorenbos

^*The Division of Clinical Endocrinology, Department of Internal Medicine, University of Groningen, Groningen, The Netherlands

› Institutsangaben

Abstract

als PDF herunterladen

Summary

The effect of induced hypothyroidism on platelet count and platelet volume distribution was studied in twelve athyreotic patients, After a two weeks withdrawal of triiodothyronine supplementation, platelet count and the ratio between platelet and red cell count were increased in all patients. Furthermore, mean platelet volume was declined and platelet distribution width was risen. Thus, hypothyroidism appears to increase the number of circulating platelets, especially the smaller ones.

Keywords

Platelet count - Platelet volume distribution - Hypothyroidism

PDF (172 kb)

Referenzen

References
1 Sjoberg RJ, Kidd GS, Swanson E, O’Barr T, Wetherill S, Corby D, Hofeldt FD. Thromboxane and prostacyclin generation in hypothyroidism. Clin Res 1984; 32: 690 A.
2 Osgood EE, Koler RD, Hughes ME. Differential diagnosis and treatment of hemorrhagic diseases. Arch Intern Med 1954; 94: 956-969
3 Edson JR, Fecher DR, Doe RP. Low platelet adhesiveness and other hemostatic abnormalities in hypothyroidism. Ann Intern Med 1975; 82: 342-346
4 Hellem AJ, Segaard E, Solem JH. The adhesiveness of human blood platelets and thyroid function. Acta Med Scand 1975; 197: 15-17
5 Endo Y. Relationship between thyroid function and platelet counts. Acta Haemat 1985; 74: 58-59
6 Van der Lelie J, Von dem Borne Jr A EG. The clinical significance of platelet volume analysis. Neth J Med 1985; 28: 457-462
7 Rowan RM, Fraser C, Gray JH, McDonald GA. The Coulter Counter Model S Plus - the shape of things to come. Clin Lab Haemat 1979; 1: 29-40
8 Hindriks FR, Wolthers BG, Groen A. The determination of total cholesterol in serum by gas-liquid chromatography compared with two other methods. Clin Chim Acta 1977; 74: 207-215
9 Das KC, Mukherjee M, Sarkar TK, Dash RJ, Rastogi GK. Erythropoiesis and erythropoietin in hypo- and hyperthyroidism. J Clin Endocrinol Metab 1975; 40: 211-220
10 Skowsky WR, Kikuchi TA. The role of vasopressin in the impaired water excretion of myxedema. Am J Med 1978; 64: 613-621
11 Bradley SE. Renal function - Body water and electrolytes. In The Thyroid. Werner SC, Ingbar SH. (eds.), p. 884-891 Harper and Row; Hagerstown-Maryland: 1978
12 Karpatkin S. Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume. Blood 1978; 51: 307-316
13 Levin J, Bessman JD. The inverse relation between platelet volume and platelet number. J Lab Clin Med 1983; 101: 295-307
14 Bessman JD. The relation of megakaryocyte ploidy to platelet volume. Am J Hematol 1984; 16: 161-170
15 Steele P, Rainwater J. Effects of dietary and pharmacologic alteration of serum lipids on platelet survival time. Circulation 1978; 58: 365-367
16 Watanabe E, Sasakawa S. Changes of platelet cell volumes in hypotonic solution. Thromb Res 1983; 31: 13-21
17 Decaux G, Efira A, Dhaene M, Unger J. Interference of serum tonicity with the measurement of red cell mean corpuscular volume. Acta Haemat 1982; 67: 62-66