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Thromb Haemost 1993; 70(01): 072-074
DOI: 10.1055/s-0038-1646163
State-of-the-Art Lecture
Factor XI
Schattauer GmbH Stuttgart

The Role of Factor XI in Coagulation

George J Broze Jr
The Jewish Hospital, Washington University Medical Center, St. Louis, MO, USA
,
David Gailani
The Jewish Hospital, Washington University Medical Center, St. Louis, MO, USA
› Author Affiliations
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Publication History

Publication Date:
03 July 2018 (online)

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  • References

  • 1 MacFarlane RG. An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature 1964; 202: 498-499
    CrossrefPubMedGoogle Scholar
  • 2 Davie EW, Ratnoff OD. Waterfall sequence for intrinsic blood clotting. Science 1964; 145: 1310-1312
    CrossrefPubMedGoogle Scholar
  • 3 Kaplan AP, Silverberg M. The coagulation-kinin pathway of human plasma. Blood 1987; 70: 1-15
    PubMedGoogle Scholar
  • 4 Østerud B, Rapaport S. Activation of factor IX by the reaction product of tissue factor and factor VII. Additional pathway for initiating blood coagulation. Proc Natl Acad Sci USA 1977; 74: 5260-5264
    CrossrefPubMedGoogle Scholar
  • 5 Broze Jr GJ, Warren LA, Novotny WF, Higuchi DA, Girard JJ, Miletich JP. The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: Insight into its possible mechanism of action. Blood 1988; 71: 335-343
    PubMedGoogle Scholar
  • 6 Broze Jr GJ, Girard TJ, Novotny WF. Regulation of coagulation by a multivalent Kunitz-type inhibitor. Biochemistry 1990; 29: 7539-7546
    CrossrefPubMedGoogle Scholar
  • 7 Rapaport SI. The extrinsic pathway inhibitor: A regulator of tissue factor-dependent blood coagulation. Thromb Haemostas 1991; 66: 6-15
    PubMedGoogle Scholar
  • 8 Rosenthal RL, Dreskin OH, Rosenthal N. Plasma thromboplastin antecedent (PTA) deficiency: Clinical, coagulation, therapeutic and hereditary aspects of a new hemophilia-like disease. Blood 1955; 10: 120-131
    PubMedGoogle Scholar
  • 9 Leiba H, Romot B, Many R. Heredity and coagulation studies in ten families with factor XI (plasma thromboplastin antecedent) deficiency. Br J Haematol 1965; 11: 654-665
    CrossrefPubMedGoogle Scholar
  • 10 Lewis JH, Spero JA, Ragni MV, Bontempo FA. Transfusion support for congenital clotting deficiencies other than haemophilia. Clin Haematol 1984; 13: 119-135
    PubMedGoogle Scholar
  • 11 Ragni MV, Sinha D, Seaman F, Lewis JH, Spero JA, Walsh PN. Comparison of bleeding tendency, factor XI coagulant activity, and factor XI antigen in 25 factor Xl-deficiency kindreds. Blood 1985; 65: 719-724
    PubMedGoogle Scholar
  • 12 Bolton-Maggs PHB, Young-Wan-Yin R, McCraw A, Slack J, Kernoff PBA. Inheritance and bleeding in factor XI deficiency. Br J Haematol 1988; 69: 521-528
    CrossrefPubMedGoogle Scholar
  • 13 Litz CE, Swaim WR, Dalmasso AP. Factor XI deficiency: Genetic and clinical studies of a single kindred. Am J Hematol 1988; 28: 8-12
    CrossrefPubMedGoogle Scholar
  • 14 Berliner S, Horowitz I, Martinowitz U, Brenner B, Seligsohn U. Dental surgery in patients with severe factor XI deficiency without plasma replacement. Blood Coag Fibrinol 1992; 3: 465-468
    CrossrefPubMedGoogle Scholar
  • 15 Komiyama Y, Masuda M, Murakami T, Nishikado H, Egawa H, Nishimura T, Morii S, Murata K. Accumulation of 125I-factor XI in atheroma of rabbit with hereditary hyperlipidemia (WHHL-rabbit). Thromb Res 1989; 56: 49-58
    CrossrefPubMedGoogle Scholar
  • 16 Loeser WD, Dickstein ES. Factor XI deficiency in a geriatric population. Ohio Med 1988; 84: 416-417
    PubMedGoogle Scholar
  • 17 Naito K, Fujikawa K. Activation of human blood coagulation factor XI independent of factor XII: Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces. J Biol Chem 1991; 266: 7353-7358
    PubMedGoogle Scholar
  • 18 Gailani D, Broze Jr GJ. Factor XI activation in a revised model of blood coagulation. Science 1991; 253: 909-912
    CrossrefPubMedGoogle Scholar
  • 19 Bouma BN, Vlooswijk RA, Griffin JH. Immunologic studies of human coagulation factor XI and its complex with high molecular weight kininogen. Blood 1983; 62: 1123-1131
    PubMedGoogle Scholar
  • 20 Scott CF, Colman RW. Fibrinogen blocks the autoactivation and thrombin-mediated activation of factor XI on dextran sulfate. Proc Natl Acad Sci USA 1992; 89: 11189-11193
    CrossrefPubMedGoogle Scholar
  • 21 Brunnee T, La Porta C, Reddigari SR, Salerno VM, Kaplan AP, Silverberg M. Activation of factor XI in plasma is dependent on factor XII. Blood 1993; 81: 580-586
    PubMedGoogle Scholar
  • 22 Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsh J. Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin Ill-independent inhibitors. J Clin Invest 1990; 86: 385-391
    CrossrefPubMedGoogle Scholar
  • 23 Walsh PN, Griffin JH. Contributions of human platelets to the proteolytic activation of blood coagulation factors XII and XI. Blood 1981; 57: 106-118
    CrossrefPubMedGoogle Scholar
  • 24 Broze Jr GJ. The role of tissue factor pathway inhibitor in a revised coagulation cascade. Semin Hematol 1992; 29: 159-169
    PubMedGoogle Scholar