von Willebrand Factor and Cardiovascular Disease

Lina Badimon; Juan J Badimon; James H Chesebro; Valentin Fuster

doi:10.1055/s-0038-1646170

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1993; 70(01): 111-118
DOI: 10.1055/s-0038-1646170

State-of-the-Art Lecture

von Willebrand Factor

Schattauer GmbH Stuttgart

von Willebrand Factor and Cardiovascular Disease

Authors

Lina Badimon

^*Cardiovascular Research Unit & Foundation, CSIC- Sant Pau, Barcelona, SPAIN

^†Cardiac Unit Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Juan J Badimon

^†Cardiac Unit Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
James H Chesebro

^†Cardiac Unit Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Valentin Fuster

^†Cardiac Unit Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Abstract

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References

References
1 Holmberg L, Nilsson IM. von Willebrand disease. Clin Haematol 1985; 14: 461-488
2 Zimmerman TS, Ruggeri ZM. von Willebrand's disease. Clin Haematol 1983; 12: 175-191
3 Ruggeri ZM. Functional domains of von Willebrand factor involved in interactions with platelets and the subendothelium. Prog Clin Biol Res 1988; 283: 219-253
4 von Rokitansky C. (A manual of pathological anatomy; vol 4). (Translated from German by GE Day) Sydenham Society; London: 1852: 261
5 Duguid JB. Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. J. Pathol Bacteriol 1946; 58: 207-212
6 Ip JH, Fuster V, Badimon L, Taubman M, Badimon J, Chesebro JH. Syndromes of accelerated atherosclerosis. Role of vascular injury and smooth muscle cell proliferation. J Am Coll Cardiol 1990; 15: 1667-1687
7 Davies MJ. Thrombosis and coronary atherosclerosis. In: Thrombolysis in Cardiovascular Disease. Julian D, Kubler WS, Morris RM. (eds). Marcel Dekker; New York: 1989. pp. 25-44
8 Woolf N, Crawford T. Fatty streaks in the aortic intima. Studies by an immune-histochemical technique. J Pathol Bacteriol 1960; 80: 405-408
9 Bini A, Fenoglio Jr JJ, Mesa-Tejada R. et al.: Identification and distribution of fibrinogen, fibrin and fibrin degradation products in atherosclerosis. Use of monoclonal antibodies. Arteriosclerosis 1989; 9: 109-121
10 Smith EB, Kean A, Grant A, Stirk C. Fate of fibrinogen in human arterial intima. Arteriosclerosis 1990; 10: 265-275
11 Ambrose JA, Winters SL, Arora RR. et al.: Angiographic evolution of coronary artery morphology in unstable angina. J Am Coll Cardiol 1986; 7: 472-478
12 Ambrose JA, Tannenbaum M, Alexoupoulos D. et al.: Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol 1988; 12: 56-62
13 Levin DC, Fallon JT. Significance of the angiographic morphology of localized coronary stenosis: histopathologic correlations. Circulation 1982; 66: 316-320
14 Hogan HG, Muhrer ME, Bogart R. A hemophilia-like disease in swine. Proc Soc Exp Biol Med 1941; 48: 217-219
15 Bowie EJW, Owen CA, Collman Pe, Thompson Jr JH, Fass DN. Tests of hemostasis in swine. Normal values in pigs affected with von Willebrand's disease. Am J Vet Res 1973; 34: 1405-1407
16 Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. Part I. New Engl J Med 1992; 326: 242-250
17 Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes. Part II. New Engl J Med 1992; 326: 310-318
18 Fuster V, Badimon L, Cohen M, Ambrose J, Badimon JJ, Chesebro JH. Insights into the pathogenesis of acute ischemic syndromes. Circulation 1988; 77: 1213-1220
19 Ross T. The pathogenesis of atherosclerosis: an update. N Engl J Med 1986; 314: 488-500
20 Berk BC, Taubman MB, Griendling KK. Thrombin-stimulated events in cultured vascular smooth muscle cells. J Biol Chem 1991; 274: 799-805
21 Shuman MA. Thrombin-cellular interactions. Ann NY Acad Sci 1986; 485: 228-239
22 Badimon L, Badimon JJ, Galvez A, Chesebro JH, Fuster V. Influence of arterial damage and wall shear rate on platelet deposition, ex vivo study in a swine model. Arteriosclerosis 1986; 6: 312-320
23 Badimon L, Turitto V, Rosemark JA, Badimon JJ, Fuster V. Characterization of a tubular flow chamber for studying platelet interaction with biologic and prosthetic materials. J Lab Clin Med 1987; 110: 706-718
24 Lassila R, Badimon JJ, Vallabhajosula S, Badimon L. Dynamic monitoring of platelet deposition on severely damaged vessel wall in flowing blood. Effects of different stenoses on thrombus growth. Arteriosclerosis 1990; 10: 306-315
25 Badimon L, Badimon JJ, Turitto VT, Vallabhajosula S, Fuster V. Platelet thrombus formation on collagen type I. A model of deep vessel injury -influence of blood rheology, von Willebrand factor and blood coagulation. Circulation 1988; 78: 1431-1442
26 Badimon L, Badimon JJ. Mechanism of arterial thrombosis in non-parallel streamlines: platelet thrombi grow at the apex of stenotic severely injured vessel wall. Experimental study in the pig model. J Clin Invest 1989; 84: 1134-1144
27 Stary HC. Evolution and progression of atherosclerotic lesions in coronary arteries of children and adults. Arteriosclerosis 1989; 9 (Suppl. 01) 119-32
28 Ku DN, Giddens DP, Zarins CK, Glagov S. Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis 1985; 5: 292-302
29 Caro CG, Parker KH, Fish PJ, Lever MJ. Flow near the arterial wall and arterial disease. Clin Hemorheol 1985; 5: 849-871
30 Fuster V, Bowie EJW, Lewis JC, Fass DN, Owen Jr CA, Brown AL. Resistance to arteriosclerosis in pigs with von Willebrand's disease. Spontaneous and high cholesterol diet-induced arteriosclerosis. J Clin Invest 1978; 61: 722-731
31 Badimon L, Steele P, Badimon JJ, Bowie EJW, Fuster V. Aortic atherosclerosis in pigs with heterozygous von Willebrand's disease. Comparison with homozygous von Willebrand and normal pigs. Arteriosclerosis 1985; 5: 366-369
32 Fuster V, Badimon L, Rosemark J, Badimon JJ, Lie J, Bowie EJW. Spontaneous and diet-induced coronary atherosclerosis in normal swine and swine with von Willebrand's disease. Arteriosclerosis 1985; 5: 67-73
33 Griggs TR, Reddick RL, Sultzer D, Brinkhous KM. Susceptibility to atherosclerosis in aortas and coronary arteries of swine with von Willebrand's disease. Am J Pathol 1985; 43: 303-309
34 Fuster V, Griggs TR. Porcine von Willebrand disease: Implications for the pathophysiology of atherosclerosis and thrombosis. In: (Progress in Hemostasis and Thrombosis; Vol 8). Coller B. (ed). Grune and Stratton; New York: 1986. pp. 159-183
35 Rand J, Badimon L, Gordon RE, Uson RR, Fuster V. Distribution of von Willebrand factor in porcine intima varies with blood type and location. Arteriosclerosis 1987; 7: 287-292
36 Reddick RL, Griggs TR, Lamb MA, Brinkhous KM. Platelet adhesion to damaged coronary arteries. Comparison in normal and von Willebrand disease swine. Proc Natl Acad Sci USA 1982; 79: 5076-5079
37 Fuster V, Fass DN, Kave MP, Josa M, Zinsmeister AR, Bowie EJW. Arteriosclerosis in normal and von Willebrand pigs. Long term prospective study and aortic transplantation study. Circ Res 1982; 51: 587-593
38 Fuster V, Badimon L, Rosemark J. et al.: Platelet-arterial wall interaction: quantitative and qualitative study following selective carotid endothelial injury in normal and von Willebrand disease pigs. Clin Res 1983; 31: 459A
39 Nichols TC, Bellinger DA, Johnson AJ, Lamb MA, Griggs TR. von Willebrand's disease prevents occlusive thrombosis in stenosed and injured porcine coronary arteries. Circ Res 1986; 59: 15-26
40 Nichols TC, Bellinger DA, Tate D. et al.: von Willebrand factor and occlusive arterial thrombosis. A study in normal and von Willebrand's disease pigs with diet-induced hypercholesterolemia and atherosclerosis. Arteriosclerosis 1990; 10: 449-461
41 Badimon L, Badimon JJ, Turitto VT, Fuster V. Platelet deposition in von Willebrand factor deficient vessel wall. J Lab Clin Med 1987; 110: 634-647
42 Badimon L, Badimon JJ, Turitto VT, Fuster V. Role of von Willebrand factor in mediating platelet-vessel wall interaction at low shear rate: the importance of perfusion conditions. Blood 1989; 73: 961-967
43 Weiss HJ. Von Willebrand Factor and platelet function. Ann NY Acad Sci 1991; 614: 125-137
44 Badimon L, Badimon JJ, Chesebro JH, Fuster V. Inhibition of thrombus formation: blockage of adhesive glycoprotein mechanisms versus blockage of the cyclooxygenase pathway. J Am Coll Cardiol 1988; 11 (suppl A) 30A
45 Badimon L, Badimon JJ, Ruggeri Z, Fuster V. A peptide-specific monoclonal antibody that inhibits von Willebrand Factor binding to GPIIb/IIIa (152B6) inhibits platelet deposition to human atherosclerotic vessel wall. Circulation 1990; 82: III-370 (#1470)
46 Cadroy Y, Kelly A, Marzec U. et al.: Comparison of the antihemo-static and antithrombotic effects of monoclonal antibodies against von Willebrand factor and platelet glycoprotein IIb/IIIa. Circulation 1989; 80 (Suppl. 02) 24
47 Badimon JJ, Fuster F, Badimon L. Inhibition of GPIb binding domain inhibits platelet deposition on damaged vessel wall. Circulation 1991; 84 (04) II-162 (A#980)
48 Ruggeri Z. Von Willebrand factor as a target for antithrombotic intervention. Circulation 1992; 86 (suppl III) III26-III29
49 Badimon L, Badimon JJ, Lassila R, Heras M, Chesebro JH, Fuster V. Effects of thrombin inhibition in porcine platelet interaction with severely damaged vessel wall, mildly damaged vessel wall and isolated fibrillar collagen type I. Hirudin and r-hirudin versus heparin in arterial thrombosis. Blood 78: 423-434 1991;
50 Badimon L, Badimon JJ, Chesebro JH, Fuster F. Inhibition of thrombosis at sites of severe wall injury: Thrombin versus ligand integrin inhibition. Circulation 1991; 84 (04) 11-162 (A#2310)
51 Silver J, Cronberg S, Nilsson IM. Occurrence of atherosclerosis in von Willebrand's disease. Acta Med Scand 1966; 180: 475-478
52 Kernoff LM, Rose AG, Hughes J. et al.: Autopsy findings in an elderly man suffering from severe von Willebrand's disease. Thromb Haemost 1981; 46: 714-716
53 Dulhoste MN, Bonnet J, Vergnes C, Choussat A, Bricaud H. Mal-adie de Willebrand et atherosclerose coronarienne. Arch Mal Coeur 1989; 82: 1875-1878
54 Mossard JM, Wiesel ML, Cazanave JP, Grunebaum L, Drawin T, Kieny JR, Roul G, Bareiss P, Sacrez A. Relations entre augmentation du facteur de Willebrand plasmatique, infarctus du myocarde aigu, angor inestable et thrombosis coronaire. Arch Mal Coeur 1989; 82: 1813-1818
55 Penny WF, Weinstein M, Salzman EW, Ware JA. Correlation of circulating von Willebrand factor levels with cardiovascular hemodynamics. Circulation 1991; 83: 1630-1636