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Thromb Haemost 1993; 70(01): 135-137
DOI: 10.1055/s-0038-1646174
State-of-the-Art Lecture
Plasminogen Activator Inhibitors
Schattauer GmbH Stuttgart

Regulation of PAI-1 Gene Expression In Vivo

David J Loskutoff
The Research Institute of Scripps Clinic, The Committee for the Study of Vascular Biology, La Jolla, CA, USA
,
Michael Sawdey
The Research Institute of Scripps Clinic, The Committee for the Study of Vascular Biology, La Jolla, CA, USA
,
Mark Keeton
The Research Institute of Scripps Clinic, The Committee for the Study of Vascular Biology, La Jolla, CA, USA
,
Jacob Schneiderman
The Research Institute of Scripps Clinic, The Committee for the Study of Vascular Biology, La Jolla, CA, USA
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Publikationsdatum:
03. Juli 2018 (online)

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  • References

  • 1 Sprengers ED, Kluft C. Plasminogen activator inhibitors. Blood 1987; 69: 381-387
    PubMedGoogle Scholar
  • 2 Loskutoff DJ, Sawdey M, Mimuro J. Type 1 plasminogen activator inhibitor. In: (Progress in Hemostasis and Thrombosis; Vol 9). Coller B. (ed) W.B. Saunders; Philadelphia: 1989. pp. 87-115
    Google Scholar
  • 3 Sawdey M, Loskutoff DJ. Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-α, and transforming growth factor-β. J Clin Invest 1991; 88: 1346-1353
    CrossrefPubMedGoogle Scholar
  • 4 Keeton M, Eguchi Y, Sawdey M, Ahn C, Loskutoff DJ. Cellular localization of type 1 plasminogen activator inhibitor mRNA and protein in murine renal tissue. Am J Path 1993; 142: 59-70
    PubMedGoogle Scholar
  • 5 Schneiderman J, Sawdey MS, Keeton MR. et al.: Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci USA 1992; 89: 6998-7002
    CrossrefPubMedGoogle Scholar
  • 6 Astrup T. The hemostatic balance. Thromb Diath Haemorrh 1958; 2: 347
    PubMedGoogle Scholar
  • 7 Nachman RL. Thrombosis and atherogenesis: Molecular connections. Blood 1992; 79: 1897-1906
    PubMedGoogle Scholar
  • 8 Schleef RR, Higgins DL, Pillemer E, Levitt JJ. Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor. J Clin Invest 1989; 83: 1747-1752
    CrossrefPubMedGoogle Scholar
  • 9 Dieval J, Nguyen G, Gross S, Delobel J, Kruithof EKO. A lifelong bleeding disorder associated with a deficiency of plasminogen activator inhibitor type 1. Blood 1991; 3: 528-532
    PubMedGoogle Scholar
  • 10 Fay WP, Shapiro AD, Shih JL, Schleef RR, Ginsburg D. Brief Report: Complete deficiency of plasminogen-activator inhibitor type 1 due to a frameshift mutation. N Engl J Med 1992; 327: 1729-1733
    CrossrefPubMedGoogle Scholar
  • 11 Pannekoek H. The function of plasminogen activator inhibitor 1 (PAI-1) in the control of thrombolysis. Biomed Prog 1993; 6: 29-31
    PubMedGoogle Scholar
  • 12 Hamsten A, De Faire U, Walldius G, Dahlen G, Szamosi A, Landou C, Blomback M, Wiman B. Plasminogen activator inhibitor in plasma: Risk factor for recurrent myocardial infarction. Lancet 1987; 2: 3-9
    PubMedGoogle Scholar
  • 13 Pralong G, Calandra T, Glauser MP. et al.: Plasminogen activator inhibitor 1: A new prognostic marker in septic shock. Thromb Haemostas 1989; 61: 459-462
    PubMedGoogle Scholar
  • 14 Erickson LA, Fici GJ, Lund JE, Boyle TP, Polites HG, Marotti KR. Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene. Nature 1990; 346: 74-76
    CrossrefPubMedGoogle Scholar
  • 15 Vaughan DE, Declerck PJ, Van Houtte E, De Mol M, Collen D. Studies of recombinant plasminogen activator inhibitor-1 in rabbits. Circ Res 1990; 67: 1281-1286
    CrossrefPubMedGoogle Scholar
  • 16 Loskutoff DJ. Regulation of PAI-1 gene expression. Fibrinolysis 1991; 5: 197-206
    PubMedGoogle Scholar
  • 17 Erickson LA, Ginsberg MH, Loskutoff DJ. Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. J Clin Invest 1984; 74: 1465-1472
    CrossrefPubMedGoogle Scholar
  • 18 Simpson AJ, Booth NA, Moore NR, Bennett B. The platelet and plasma pools of plasminogen activator inhibitor (PAI-1) vary independently in disease. Br J Haematol 1990; 75: 543-548
    CrossrefPubMedGoogle Scholar
  • 19 Quax PHA, van den Hoogen CM, Verheijen JH. et al.: Endotoxin induction of plasminogen activator and plasminogen activator inhibitor type 1 mRNA in rat tissues in vivo . J Biol Chem 1990; 265: 15560-15563
    PubMedGoogle Scholar