Nitric Oxide-mediated Vasorelaxation

Louis J Ignarro

doi:10.1055/s-0038-1646177

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1993; 70(01): 148-151
DOI: 10.1055/s-0038-1646177

State-of-the-Art Lecture

Vascular Wall Biology

Schattauer GmbH Stuttgart

Nitric Oxide-mediated Vasorelaxation

Louis J Ignarro

Department of Pharmacology, UCLA School of Medicine, Los Angeles, CA, USA

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Referenzen

References
1 Gruetter CA, Barry BK, McNamara DB, Gruetter DY, Kadowitz PJ, Ignarro LJ. Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. J Cyclic Nucleotide Protein Phosphoryl Res 1979; 5: 211-224
2 Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376
3 Mellion BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ. Evidence for the inhibitory role of guanosine 3',5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood 1981; 57: 946-955
4 Gruetter CA, Gruetter DY, Lyon JE, Kadowitz PJ, Ignarro LJ. Relationship between cyclic GMP formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin. J Pharmacol Exp Ther 1981; 219: 181-186
5 Ignarro LJ, Lippton H, Edwards JC, Baricos WH, Hyman AL, Kadowitz PJ, Gruetter CA. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiols as active intermediates. J Pharmacol Exp Ther 1981; 218: 739-749
6 Waldman SA, Murad F. Cyclic GMP synthesis and function. Pharmacol Rev 1987; 39: 163-208
7 Twort CH, Van Breemen C. Cyclic GMP enhanced sequestration of Ca²⁺ by sarcoplasmic reticulum in vascular smooth muscle. Circ Res 1988; 62: 961-964
8 Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987; 84: 9265-9269
9 Ignarro LJ, Byrns RE, Buga GM, Wood KS. Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacological and chemical properties that are identical to those for nitric oxide radical. Circ Res 1987; 61: 866-879
10 Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-526
11 Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988; 333: 664-666
12 Marietta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS. Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate. Biochemistry 1988; 27: 8706-8711
13 Bredt DS, Snyder SH. Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 1990; 87: 682-685
14 Sakuma I, Stuehr DJ, Gross SS, Nathan CF, Levi R. Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc Natl Acad Sci USA 1988; 85: 8664-8667
15 Palmer RMJ, Rees DD, Ashton DS, Moncada S. L-Arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 1988; 153: 1251-1256
16 Katsuki S, Arnold W, Mittal C, Murad F. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of NaN₃ and NH₂OH. J Cyclic Nucleotide Protein Phosphoryl Res 1977; 3: 23-35
17 Ignarro LJ, Kadowitz PJ. The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Ann Rev Pharmacol Toxicol 1985; 25: 171-191
18 Ignarro LJ, Gruetter CA. Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: Possible involvement of S-nitrosothiols. Biochim Biophys Acta 1980; 631: 221-231
19 Mellion BT, Ignarro LJ, Myers CB, Ohlstein EH, Ballot BA, Hyman AL, Kadowitz PJ. Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation. Mol Pharmacol 1983; 23: 653-664
20 Cherry PD, Furchgott RF, Zawadzki JV, Jothianandan D. Role of endothelial cells in relaxation of isolated arteries by bradykinin. Proc Natl Acad Sci USA 1982; 72: 2106-2110
21 Pohl U, Holtz J, Busse R, Bassenge E. Critical role of endothelium in the vasodilator response to increased flow in vivo . Hypertension 1986; 8: 37-44
22 Buga GM, Gold ME, Fukuto JM, Ignarro LJ. Shear-stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension 1991; 17: 187-193
23 Buga GM, Ignarro LJ. Electrical field stimulation causes endothelium-dependent and nitric oxide-mediated relaxation of pulmonary artery. Am J Physiol 1992; 262: H973-H979
24 Toda N, Okamura T. Possible role of nitric oxide in transmitting information from vasodilator nerves to cerebroarterial muscle. Biochem Biophys Res Commun 1990; 170: 308-313
25 Sanders KM, Ward SM. Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am J Physiol 1992; 262: G379-G392
26 Gillespie JS, Liu X, Martin W. The effects of L-arginine and N^G-monomethyl-L-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation. Br J Pharmacol 1989; 98: 1080-1082
27 Hobbs AJ, Gibson A. L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus. Br J Pharmacol 1990; 100: 747-752
28 Ramagopal MW, Leighton HJ. Effects of N^G-monomethyl-L-arginine on field stimulation-induced decreases in cytosolic Ca²⁺ levels and relaxation in the rat anococcygeus muscle. Eur J Pharmacol 1989; 174: 297-299
29 Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys Res Commun 1990; 170: 843-850
30 Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Eng J Med 1992; 326: 90-94
31 Forstermann U, Schmidt HHHW, Pollock JS, Sheng H, Mitchell JA, Warner TD, Nakane M, Murad F. Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem Pharmacol 1991; 42: 1849-1857
32 Snyder SH, Bredt DS. Biological roles of nitric oxide. Scientific American 1992; May 68-77
33 Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 1992; 256: 225-228
34 Hibbs JB, Taintor RR, Vavrin Z, Rachlin EM. Nitric oxide: A cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res Commun 1988; 157: 87-94
35 Stuehr DJ, Gross SS, Sakuma I, Levi R, Nathan CF. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of EDRF and the chemical reactivity of nitric oxide. J Exp Med 1989; 169: 1011-1020
36 Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6: 3051-3064
37 Busse R, Mulsch A. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells. FEBS Lett 1990; 275: 87-90
38 Thiemermann C, Vane J. Inhibition of nitric oxide synthesis reduces the hypertension induced by bacterial lipopolysaccharides in the rat in vivo . Eur J Pharmacol 1990; 182: 591-595
39 Kilbourn RG, Jubran A, Gross SS, Griffith OW, Levi R, Adams J, Lodato RF. Biochem Biophys Res Commun. 1991; 172: 1132-1138
40 Kilbourn RG, Gross SS, Jubran A, Adams J, Griffith OW, Levi R, Lodato RF. N^G-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci USA 1990; 87: 3629-3632
41 Wolin MS, Wood KS, Ignarro LJ. Guanylate cyclase from bovine lung: A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. J Biol Chem 1982; 257: 13312-13320
42 Ignarro LJ, Wood KS, Wolin MS. Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: A unifying concept. Adv Cyclic Nucleotide Prot Phosphoryl Res. 1984; 17: 267-274
43 Ignarro LJ, Wood KS, Ballot B, Wolin MS. Guanylate cyclase from bovine lung: Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes. J Biol Chem 1984; 259: 5923-5931
44 Ignarro LJ, Ballot B, Wood KS. Regulation of soluble guanylate cyclase activity by porphyrins and metalloporphyrins. J Biol Chem 1984; 259: 6201-6207
45 Rogers NE, Ignarro LJ. Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine. Biochem Biophys Res Commun 1992; 189: 242-249