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Thromb Haemost 1993; 70(01): 158-162
DOI: 10.1055/s-0038-1646180
State-of-the-Art Lecture
Thrombin
Schattauer GmbH Stuttgart

The Role of Thrombin and Thrombin Receptor Activating Peptide (TRAP-508) in Initiation of Tissue Repair

Janet Stiernberg
Department of Human Biological Chemistry & Genetics, The University of Texas Medical Branch, Galveston, TX, 77555-0645, USA
,
William R Redin
Department of Human Biological Chemistry & Genetics, The University of Texas Medical Branch, Galveston, TX, 77555-0645, USA
,
W Scott Warner
Department of Human Biological Chemistry & Genetics, The University of Texas Medical Branch, Galveston, TX, 77555-0645, USA
,
Darrell H Carney
Department of Human Biological Chemistry & Genetics, The University of Texas Medical Branch, Galveston, TX, 77555-0645, USA
› Author Affiliations
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Publication History

Publication Date:
03 July 2018 (online)

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  • References

  • 1 Carney DH. Postclotting cellular effects of thrombin mediated by interaction with high-affinity thrombin receptors. In: Thrombin Structure and Function.. Berliner L. (ed). Plenum; New York: 1992. pp. 351-396
    Search in Google Scholar
  • 2 Carney DH, Glenn KC, Cunningham DD. Conditions which affect initiation of animal cell division by trypsin and thrombin. J Cellul Physiol 1978; 95: 13-22
    CrossrefPubMedSearch in Google Scholar
  • 3 Carney DH, Cunningham DD. Role of specific cell surface receptors in thrombin-stimulated cell division. Cell 1978; 15: 1341-1349
    CrossrefPubMedSearch in Google Scholar
  • 4 Carney DH, Glenn KC, Cunningham DD, Das M, Fox CF, Fenton II JW. Photoaffinity labeling of a single receptor for alpha thrombin on mouse embryo cells. J Biol Chem 1979; 254: 6244-6247
    PubMedSearch in Google Scholar
  • 5 Carney DH, Bergmann JS. 125I-Thrombin binds to clustered receptors on noncoated regions of mouse embryo cell surfaces. J Cell Biol 1982; 95: 697-703
    CrossrefPubMedSearch in Google Scholar
  • 6 Carney DH. Immunofluorescent visualization of specifically bound thrombin reveals cellular heterogeneity in number and density of preclustered receptors. J Cell Physiol 1983; 117: 297-307
    CrossrefPubMedSearch in Google Scholar
  • 7 Frost GH, Thompson WC, Carney DH. Monoclonal antibody to the thrombin receptor stimulates DNA synthesis in combination with gamma-thrombin or phorbol myristate acetate. J Cell Biol 1987; 105: 2551-2558
    CrossrefPubMedSearch in Google Scholar
  • 8 Frost GH, Bergmann JS, Carney DH. Glycosylation of high-affinity thrombin receptors is necessary for thrombin binding. Biochem Biophys Res Commun 1991; 180: 349-355
    CrossrefPubMedSearch in Google Scholar
  • 9 Carney DH. Characterization of the thrombin receptor and its involvement in initiation of cell proliferation. In: Control of Animal Cell Proliferation. Boynton AL, Leffert HL. (eds). Academic Press; Orlando, FL: 1987. pp. 265-296
    CrossrefSearch in Google Scholar
  • 10 Carney DH, Redin WR, McCroskey L. Role of high-affinity thrombin receptors in postclotting effects of thrombin. Semin Thromb Hemostas 1992; 18: 91-103
    Thieme ConnectPubMedSearch in Google Scholar
  • 11 Carney DH, Scott DL, Gordon EA, LaBelle EF. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Cell 1985; 42: 479-488
    CrossrefPubMedSearch in Google Scholar
  • 12 Gordon EA, Carney DH. Thrombin receptor occupancy initiates cell proliferation in the presence of phorbol myristic acetate. Biochem Biophys Res Commun 1986; 141: 650-656
    CrossrefPubMedSearch in Google Scholar
  • 13 Stiernberg J, Carney DH, Fenton II JW, LaBelle EF. Initiation of DNA synthesis by human thrombin: relationships between receptor binding, enzymic activity, and stimulation of 86Rb+ influx. J Cellul Physiol 1984; 120: 289-295
    CrossrefPubMedSearch in Google Scholar
  • 14 Kim DW, Carney DH. Thrombin induction of c-myc and c-fos occurs through a specific subset of signals generated by thrombin-receptor interactions. J Cell Biol 1991; 115: 16a
    PubMedSearch in Google Scholar
  • 15 Carney DH, Herbosa GJ, Stiernberg J, Bergmann JS, Gordon EA, Scott D, Fenton II JW. Double-signal hypothesis for thrombin initiation of cell proliferation. Semin Thromb Hemostas 1986; 12: 231-240
    Thieme ConnectPubMedSearch in Google Scholar
  • 16 Gordon EA, Fenton II JW, Carney DH. Thrombin-receptor occupancy initiates a transient increase in cAMP levels in mitogenically responsive hamster (NIL) fibroblasts. Ann NY Acad Sci 1986; 485: 249-263
    CrossrefPubMedSearch in Google Scholar
  • 17 Vu T-KH, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068
    CrossrefPubMedSearch in Google Scholar
  • 18 Rasmussen UB, Craviari VV, Jallat S, Schlesinger Y, Pages G, Pavirani A, Lecocq JP, Pouyssegur J, Van Obberghen-Shilling E. cDNA cloning and expression of a hamster thrombin receptor coupled to Ca++ mobilization. FEBS Lett 1991; 288: 123-128
    CrossrefPubMedSearch in Google Scholar
  • 19 Zhong C, Hayzer DJ, Corson MA, Runge MS. Molecular cloning of the rat vascular smooth muscle thrombin receptor: Evidence for in vitro regulation by basic fibroblast growth factor. J Biol Chem 1992; 267: 1-5
    PubMedSearch in Google Scholar
  • 20 Vouret-Craviari V, Van Obberghen-Shilling E, Rasmussen UB, Pavirani A, Lecocq JP, Pouyssegur J. Synthetic a-thrombin receptor peptides activate G protein-coupled signaling pathways, but are unable to induce mitogenesis. Mol Biol Cell 1992; 3: 95-102
    CrossrefPubMedSearch in Google Scholar
  • 21 Glenn KC, Frost GH, Bergmann JS, Carney DH. Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis. Peptide Res 1988; 1: 65-73
    PubMedSearch in Google Scholar
  • 22 Carney DH, Mann R, Redin WR, Pernia SD, Berry D, Heggers JP, Hayward PG, Robson MC, Christie J, Annable C, Fenton II JW, Glenn KC. Enhancement of incisional wound healing and neovascularization in rats by thrombin and synthetic thrombin receptor-activating peptides. J Clin Invest 1992; 89: 1469-1477
    CrossrefPubMedSearch in Google Scholar
  • 23 Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF. Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science 1987; 237: 1333-1336
    CrossrefPubMedSearch in Google Scholar
  • 24 Pierce GF, Mustoe TA, Senior RM, Reed J, Griffin GL, Thomason A, Deuel TF. In vivo incisional wound healing augmented by platelet-derived growth factor and recombinant c-sis gene homodi-meric proteins. J Exp Med 1988; 167: 974-87
    CrossrefPubMedSearch in Google Scholar
  • 25 Mustoe TA, Purdy J, Gramates P, Deuel TF, Thomason A, Pierce GF. Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB. Am J Surg 1989; 158: 345-50
    CrossrefPubMedSearch in Google Scholar
  • 26 Brown GL, Curtsinger LJ, White M, Mitchell RO, Pietsch J, Nordquist R, von FA, Schultz GS. Acceleration of tensile strength of incisions treated with EGF and TGF-beta. Ann Surg 1988; 208788-94
    PubMedSearch in Google Scholar
  • 27 Pernia SD, Berry DL, Redin WR, Carney DH. A synthetic peptide representing the thrombin receptor-binding domain enhances wound closure in vivo . Southern Assn Agr Sci 1990; 3: 8-12
    PubMedSearch in Google Scholar
  • 28 Leitzel K, Cano C, Marks JGJ, Lipton A. Growth factors and wound healing in the hamster. J Dermatol Surg Oncol 1985; 11 (06) 617-22
    CrossrefPubMedSearch in Google Scholar
  • 29 Cromack DT, Purdy JA, Porras-Reyes B, Mustoe TA. Acceleration of tissue repair by transforming growth factor-β: In vivo mechanism of action by selective radiotherapy impaired healing. Surg Forum 1990; (04) 630-632
    PubMedSearch in Google Scholar
  • 30 Cromack DT, Porras-Reyes BH, Wee SS, Glenn KC, Pardee JA, HC D, Mustoe TA. Acceleration of soft tissue repair by thrombin receptor-activating peptide (p517-530): Use of radiotherapy induced healing defect to define repair mechanism. J Surg Res 1992; 53: 117-122
    CrossrefPubMedSearch in Google Scholar
  • 31 Goslen JB. Wound healing for the dermatologic surgeon. J Dermatol Surg Oncol 1988; 14: 959-972
    CrossrefPubMedSearch in Google Scholar
  • 32 Malik AB. Thrombin-induced endothelial injury. Semin Thromb Hemostas 1986; 12: 184-196
    Thieme ConnectPubMedSearch in Google Scholar
  • 33 Zimmerman GA, McIntyre TM, Prescott SM. Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. Ann N Y Acad Sci 1986; 485: 349-368
    CrossrefPubMedSearch in Google Scholar
  • 34 Bizios R, Lai LC, Cooper JA, Del Vecchio PJ, Malik AB. Thrombin-induced adherence of neutrophils to cultured endothelial monolayers: Increased endothelial adhesiveness. J Cellul Physiol 1988; 134: 275-280
    CrossrefPubMedSearch in Google Scholar
  • 35 Bevilacqua MP, Stengelin S, Gimbrone MAJ, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 1989; 243: 1160-1165
    CrossrefPubMedSearch in Google Scholar
  • 36 Saegusa Y, Cavender D, Ziff M. Stimulation of mononuclear cell binding to human endothelial cell monolayers by thrombin. J Immunol 1988; 141: 4140-4145
    PubMedSearch in Google Scholar
  • 37 Bar-Shavit R, Kahn AJ, Mann KG, Wilner GD. Growth-promoting effects of esterolytically inactive thrombin on macrophages. J Cellul Biochem 1986; 32: 261-72
    PubMedSearch in Google Scholar
  • 38 Naldini A, Carney DH, Bocci V, Klimpel GR. Thrombin enhances T cell activation. J Cellul Immunol. 1993 In Press
    PubMedSearch in Google Scholar
  • 39 Krawczyk WS. The pattern of epidermal cell migration during wound healing. J Cell Biol 1971; 49: 247-263
    CrossrefPubMedSearch in Google Scholar
  • 40 Belloni PN, Carney DH, Nicolson GL. Isolation and characterization of murine and human endothelial cells from various organs: Differential responsiveness to thrombin and other growth factors. Microvasc Res 1992; 43: 20-45
    CrossrefPubMedSearch in Google Scholar
  • 41 McDonald JA, Kelley DG, Broekelmann TJ. Role of fibronectin in collagen deposition: Fab' antibodies to the gelatin binding domain of fibronectin inhibits both fibronectin and collagen organization in fibroblast extracellular matrix. J Cell Biol 1982; 92: 485-492
    CrossrefPubMedSearch in Google Scholar
  • 42 Russell HK. A modification of Movat's pentachrome stain. Arch Path 1972; 94: 187-191
    PubMedSearch in Google Scholar
  • 43 McGrath MH. Peptide growth factors and wound healing. Clin Plast Surg 1990; 17: 421-432
    PubMedSearch in Google Scholar
  • 44 Carney DH, Redin W, Paulley V, Carraway K, Warner S. Effects of thrombin receptor activating peptide (TRAP) on closure of full dermal excisions in diabetic mice. J Cellul Biochem 1991; 15F: 193a
    PubMedSearch in Google Scholar