Signaling Pathways of the Thrombin Receptor

Ellen Van Obberghen-Schilling; Jacques Pouysségur

doi:10.1055/s-0038-1646181

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1993; 70(01): 163-167
DOI: 10.1055/s-0038-1646181

State-of-the-Art Lecture

Thrombin

Schattauer GmbH Stuttgart

Signaling Pathways of the Thrombin Receptor

Authors

Ellen Van Obberghen-Schilling

Centre Biochimie CNRS-INSERM, Nice, FRANCE
Jacques Pouysségur

Centre Biochimie CNRS-INSERM, Nice, FRANCE

Abstract

PDF Download

PDF (1672 kb)

References

References
1 Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci 1992; 17: 368-374
2 Vu TKH, Hung D, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068
3 Rasmussen UB, Vouret-Craviari V, Jallat S, Schlesinger Y, Pagès G, Pavirani A, Lecocq JP, Pouysségur J, Van Obberghen-Schilling E. cDNA cloning and expression of a hamster α-thrombin receptor coupled to Ca²⁺ mobilization. FEBS Lett 1991; 288: 123-128
4 Zhong C, Hayzer DJ, Corson MA, Runge MS. Molecular cloning of the rat vascular smooth muscle thrombin receptor. J Biol Chem 1992; 267: 16975-16979
5 Nathans J. Rhodopsin: Structure, function and genetics. Biochemistry 1992; 31: 4923-4930
6 Savarese TM, Fraser CM. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem J 1992; 283: 1-19
7 Bode W, Schwager P, Huber R. The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. J Mol Biol 1978; 118: 99-112
8 Vouret-Craviari V, Van Obberghen-Schilling E, Rasmussen UB, Pavirani A, Lecocq JP, Pouysségur J. Synthetic α-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis. Mol Biol Cell 1992; 3: 95-102
9 Vassallo RR, Kieber-Emmons T, Cichowski K, Brass LF. Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides. J Biol Chem 1992; 267: 6081-6085
10 Scarborough RM, Naughton MA, Teng W, Huang DT, Rose J, Vu T-KH, Wheaton VI, Turck CW, Coughlin SR. Tethered ligand agonist peptides. J Biol Chem 1992; 287: 13146-13149
11 Chao BH, Kalkunte S, Maraganore JM, Stone SR. Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochemistry 1992; 31: 6175-6178
12 Van Obberghen-Schilling E, Rasmussen UB, Vouret-Craviari V, Lentes KU, Pavirani A, Pouysségur J. Structure-activity analysis of synthetic α-thrombin receptor activating peptides. Biochem J. 1993 in press
13 L'Allemain G, Paris S, Magnaldo I, Pouysségur J. a-thrombin-induced inositol phosphate formation in GO-arrested and cycling hamster lung fibroblasts: evidence for a protein kinase C-mediated desensitization response. J Cell Physiol 1986; 129: 167-174
14 Magnaldo I, Pouysségur J, Paris S. Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts: an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C. Biochem J 1988; 253: 711-719
15 McKenzie FR, Seuwen K, Pouysségur J. Stimulation of phosphatidylcholine breakdown by thrombin and carbachol but not by tyrosine kinase receptor ligands in cells transfected with Ml muscarinic receptors. J Biol Chem 1992; 267: 22759-22769
16 Brass LW, Woolkalis MJ. Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties. Biochem J 1992; 281: 73-80
17 Paris S, Pouysségur J. Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na⁺/H⁺ exchange in hamster fibroblasts. EMBO J 1986; 5: 55-60
18 Chambard JC, Paris S, L'Allemain G, Pouysségur J. Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin. Nature 1987; 326: 800-803
19 Brass LF, Laposata F, Banga HS, Rittenhouse SE. Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. J Biol Chem 1986; 261: 16833-16847
20 Huang CL, Ives HE. Guanosine 5'-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells. J Biol Chem 1989; 264: 4391-4397
21 Brock TA, Capasso EL. GTPγS increases thrombin-mediated inositol trisphosphate accumulation in permeabilized human endothelial cells. Am Rev Respir Dis 1989; 140: 1121-1125
22 Garcia JGN, Painter RG, Fenton JWI, English D, Callahan KS. Thrombin-induced prostacyclin biosynthesis in human endothelium: role of guanine nucleotide regulatory proteins in stimulus/coupling responses. J Cell Physiol 1990; 142: 186-193
23 Helper J, Gilman AG. G proteins. Trends Biochem Sci 1992; 17: 383-387
24 Wu D, Lee C-H, Rhee SG, Simon MI. Activation of phospholipase C by the α subunits of the G_q and G₁₁ proteins in transfected Cos-7 cells. J Biol Chem 1992; 267: 1811-1817
25 Wu D, Katz A, Lee CH, Simon MI. Activation of phospholipase C by α₁-adrenergic receptors is mediated by the a subunits of the Gq family. J Biol Chem 1992; 267: 25798-25802
26 Hung DT, Wong YH, Vu TKH, Coughlin SR. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem 1992; 267: 20831-20834
27 Birnbaumer L. Receptor-to-effector signaling through G proteins: roles for βγ dimers as well as α subunits. Cell 1992; 71: 1069-1072
28 Paris S, Chambard JC, Pouysségur J. Tyrosine kinase-activating growth factors potentiate thrombin- and A1F^- ₄ -induced phosphoinositide breakdown in hamster fibroblasts: evidence for positive cross-talk between the two mitogenic signaling pathways. J Biol Chem 1988; 263: 12893-12900
29 Méloche S, Seuwen K, Pagès G, Cobb MH, Pouysségur J. Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity. Mol Endocrinol 1992; 6: 845-854
30 Vouret-Craviari V, Van Obberghen-Schilling E, Scimeca JC, Van Obberghen E, Pouysségur J. Differential activation of p44^mapk (ERK1) by α-thrombin and synthetic receptor peptide agonists. Biochem J 1993; 289: 209-214
31 Seuwen K, Kahan C, Hartmann T, Pouysségur J. Strong and persistent activation of inositol lipid breakdown induces early mitogenic events but not Go to S phase progression in hamster fibroblasts. J Biol Chem 1990; 265: 22292-22299
32 Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. α₂-Adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human α2-adrenergic receptor gene. Cell Regul 1990; 1: 445-451
33 Van Obberghen-Schilling E, Vouret-Craviari V, Haslam RJ, Chambard JC, Pouysségur J. Cloning, functional expression and role in cell growth regulation of a hamster 5-HT2 receptor subtype. Mol Endocrinol 1991; 5: 881-889
34 Pouysségur J, Chambard JC, Franchi A, L'Allemain G, Paris S. Van Obberghen-Schilling E. Growth factor activation of the Na⁺/H⁺ antiporter controls growth of fibroblasts by regulating intracellular pH. In: Cancer Cells. Feramisco J, Ozanne B, Stiles C. (eds). Cold Spring Harbor Laboratory, Cold Spring Harbor; New York: 1985. pp. 409-415
35 Sardet C, Counillon L, Franchi A, Pouysségur J. Growth factors induce phosphorylation of the Na⁺/H⁺ antiporter, a glycoprotein of 110kD. Science 1990; 247: 723-726
36 Livne AA, Sardet C, Pouysségur J. The Na⁺/H⁺ exchanger is phosphorylated in human platelets in response to activating agents. FEBS Lett 1991; 284: 219-222
37 Cobb M, Robbins DJ, Boulton TG. ERK's, extracellular signal-regulated MAP-2 kinases. Current Opin Cell Biol 1992; 3: 1025-1032
38 Lenormand P, Pagès G, Sardet C, L'Allemain G, Méloche S, Pouysségur J. MAP kinases: activation, subcellular localization and role in the control of cell proliferation. In: (Advances in Second Messenger and Phosphoprotein Research; Vol. 28). Markovac J. (ed). Raven Press; New York: 1993. pp. 237-244
39 Chen R-H, Sarnecki C, Blenis J. Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol Cell Biol 1992; 12: 915-927
40 Crews CM, Alessandrini A, Erikson RL. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 1992; 258: 478-480
41 Ashworth A, Nakielny S, Cohen P, Marshall C. The amino acid sequence of a mammalian MAP kinase kinase. Oncogene 1992; 7: 2555-2556
42 Kyriakis JM, App H, Zhan X, Banerjee P, Brautigan DL, Rapp UR, Avruch J. Raf-1 activates MAP kinase-kinase. Nature 1992; 358: 417-421
43 Dent P, Haser W, Haystead TAJ, Vincent LA, Roberts TM, Sturgill TW. Activation of mitogen-activated protein kinase kinase by v-raf in NIH 3T3 cells and in vitro. Nature 1992; 257: 1404-1407
44 Lin L-L, Wartmann M, Lin AY, Knopf JL, Seth A, Davis RJ. cPLA₂ is phosphorylated and activated by MAP kinase. Cell 1993; 72: 269-278
45 Susa M, Olivier AR, Fabbro D, Thomas G. EGF induces biphasic S6 kinase activation: late phase is protein kinase C-dependent and contributes to mitogenicity. Cell 1989; 57: 817-824
46 Kahan C, Seuwen K, Meloche S, Pouysségur J. Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. J Biol Chem 1992; 267: 13369-13375
47 Ferrell Jr. JE, Martin GS. Platelet tyrosine-specific protein phosphorylation is regulated by thrombin. Mol Cell Biol 1988; 8: 3603-3610
48 Golden A, Brugge JS. Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc Natl Acad Sci USA 1989; 86: 901-905
49 Lipfert L, Haimovich B, Schallar MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase ppl25^FAK in platelets. J Cell Biol 1992; 119: 905-912
50 Shaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT. ppl25^FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci USA 1992; 89: 5192-5196
51 Van Obberghen-Schilling E, Chambard JC, Paris S, L'Allemain G, Pouysségur J. α-Thrombin-induced early mitogenic signalling events and GO to S-phase transition of fibroblasts require continual external stimulation. EMBO J 1985; 4: 2927-2932
52 Hunter T, Karin M. The regulation of transcription by phosphorylation. Cell 1992; 70: 375-387
53 Daniel TO, Gibbs VC, Milfay DF, Garavoy MR, Williams LT. Thrombin stimulates c-sis gene expression in microvascular endothelial cells. J Biol Chem 1986; 261: 9579-9582
54 Weiss RH, Ives HE. Dissociation between activation of growth-related genes and mitogenic responses of neonatal vascular smooth muscle cells. Biochem Biophys Res Comm 1991; 181: 617-622