Thromb Haemost 1993; 70(01): 202-203
DOI: 10.1055/s-0038-1646190
State-of-the-Art Lecture
Gene Therapy
Schattauer GmbH Stuttgart

Direct Gene Transfer: Basic Studies and Human Therapies

Elizabeth G Nabel
Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA
,
Gary J Nabel
Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2018 (online)

 
  • References

  • 1 Nabel EG, Plautz G, Boyce FM, Stanley JC, Nabel GJ. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 1989; 244: 1342-1344
  • 2 Nabel EG, Plautz G, Nabel GJ. Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science 1990; 249: 1285-1288
  • 3 Plautz G, Nabel EG, Nabel GJ. Introduction of vascular smooth muscle cells expressing recombinant genes in vivo . Circulation 1991; 83: 578-583
  • 4 Lim CS, Chapman GD, Gammon RS. et al.: Direct in vivo gene transfer into the coronary and peripheral vasculatures of the intact dog. Circulation 1991; 83: 2007-2011
  • 5 Chapman GD, Lim CS, Gammon RS. et al.: Gene transfer into coronary arteries of intact animals with a percutaneous balloon catheter. Circ Res 1992; 71: 27-33
  • 6 Lynch CM, Clowes MM, Osborne WR, Clowes AW, Miller AD. Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model for gene therapy. Proc Natl Acad Sci USA 1992; 89: 1138-1142
  • 7 Leclerc G, Gal D, Takeshita S, Nikol S, Weir L, Isner JM. Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries. J Clin Invest 1992; 90: 936-944
  • 8 Nabel EG, Plautz G, Nabel GJ. Transduction of a foreign histocompatibility gene into the arterial wall induces vasculitis. Proc Natl Acad Sci USA 1992; 89: 5157-5161
  • 9 Nabel EG, Liptay S, Yang Z. et al.: Recombinant platelet-derived growth factor B gene expression in porcine arteries induces intimal hyperplasia in vivo . J Clin Invest 1993; 91: 1822-1829
  • 10 Nabel EG, Yang Z, Plautz G. et al. Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo . Nature. 1993 in press
  • 11 Plautz GE, Yang ZY, Wu B, Gao X, Huang L, Nabel GJ. Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc Natl Acad Sci USA. 1993 in press
  • 12 Nabel EG, Gordon D, Xang ZY. et al.: Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther 1992; 3: 649-656
  • 13 Nabel GJ, Chang A, Nabel EG. et al.: Clinical protocol. Immunotherapy of malignancy by in vivo gene transfer into tumors. Hum Gene Ther 1992; 3: 399-410