Download PDF
Thromb Haemost 1993; 70(01): 204-207
DOI: 10.1055/s-0038-1646191
State-of-the-Art Lecture
Anticoagulation
Schattauer GmbH Stuttgart

Low Molecular Weight Heparin

Jack Hirsh
Professor of Medicine, McMaster University, Hamilton, Ontario, CANADA
› Author Affiliations
Further Information

Publication History

Publication Date:
03 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints
 

  • References

  • 1 Hirsh J, Levine MN. Low molecular weight heparin. Blood 1992; 79: 1-17
    PubMedSearch in Google Scholar
  • 2 Andersson LO, Barrowcliffe TW, Holmer E, Johnson EA, Sims GEC. Anticoagulant properties of heparin fractionated by affinity chromatography on matrix-bound antithrombin III and by gel filtration. Thromb Res 1976; 9: 575-583
    CrossrefPubMedSearch in Google Scholar
  • 3 Hirsh J. Heparin. N Engl J Med 1991; 324: 1565-1574
    CrossrefPubMedSearch in Google Scholar
  • 4 Rosenberg RD. The heparin-antithrombin system: a natural anticoagulant mechanism. In: Hemostasis and Thrombosis; Basic Principles and Clinical Practice, 3rd edition. Colman RW, Hirsh J, Marder VJ, Salzman EW. (eds) JB Lippincott; Philadelphia: 1993. in press
    Search in Google Scholar
  • 5 Choay J, Petitou M, Lormeau JC, Sinay P, Casu B, Gatti G. Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Biochem Biophys Res Comm 1983; 116: 492-499
    CrossrefPubMedSearch in Google Scholar
  • 6 Bjork I, Lindahl U. Mechanism of the anticoagulant action of heparin. Mol Cell Biochem 1982; 48: 161-182
    CrossrefPubMedSearch in Google Scholar
  • 7 Maimone MM, Tollefsen DM. Activation of heparin cofactor II by heparin oligosaccharides. Biochem Biophys Res Commmun 1988; 152: 1056
    CrossrefPubMedSearch in Google Scholar
  • 8 Young E, Prins M, Levine MN, Hirsh J. Heparin binding to plasma proteins, an important mechanism for heparin resistance. Thromb Haemostas 1992; 67 (06) 639-643
    PubMedSearch in Google Scholar
  • 9 Barzu T, Molho P, Tobelem G, Petitou M, Caen JP. Binding of heparin and low molecular weight heparin fragments to human vascular endothelial cells in culture. Nouv Rev Fr Haematol 1984; 26: 243-247
    PubMedSearch in Google Scholar
  • 10 Salzman EW, Rosenberg RD, Smith MH, Lindon JN, Favreau L. Effect of heparin and heparin fractions on platelet aggregation. J Clin Invest 1980; 65: 64-73
    CrossrefPubMedSearch in Google Scholar
  • 11 Bara L, Samama MM. Pharmacokinetics of low molecular weight heparins. Acta Chir Scand 1990; 556: 57-61
    PubMedSearch in Google Scholar
  • 12 Harenberg J. Pharmacology of low molecular weight heparins. Sem Thromb Hemostas 1990; 16: 12
    PubMedSearch in Google Scholar
  • 13 Boneu B, Caranobe C, Cadroy Y, Dol F, Gabaig AM, Dupouy D, Sie P. Pharmacokinetic studies of standard unfractionated heparin, and low molecular weight heparins in the rabbit. Sem Thromb Hemostas 1988; 14: 18-27
    Thieme ConnectPubMedSearch in Google Scholar
  • 14 Handeland GF, Abildgaard U, Holm HA, Arnesen KE. Dose adjusted heparin treatment of deep venous thrombosis: a comparison of unfractionated and low molecular weight heparin. Eur J Clin Pharmacol 1990; 39: 107-112
    CrossrefPubMedSearch in Google Scholar
  • 15 Fernandez F, Nguyen P, Van Ryn J, Ofosu FA, Hirsh J, Buchanan MR. Hemorrhagic doses of heparin and other glycosaminoglycans induce a platelet defect. Thromb Res 1986; 43: 491-495
    CrossrefPubMedSearch in Google Scholar
  • 16 Carter CJ, Kelton JG, Hirsh J, Cerskus AL, Santos AV, Gent M. The relationship between the hemorrhagic and antithrombotic properties of low molecular weight heparins and heparin. Blood 1982; 59: 1239-1245
    PubMedSearch in Google Scholar
  • 17 Hull RD, Raskob GE, Pineo GF, Green D, Trowbridge AA, Elliott CG. A randomized double-blind trial of low molecular weight heparin in the initial treatment of proximal vein thrombosis. Thromb Haemostas 1991; 65 (Suppl) 872
    PubMedSearch in Google Scholar
  • 18 Prandoni P. Fixed dose LMW heparin (CY216) as compared with adjusted dose intravenous heparin in the initial treatment of symptomatic proximal venous thrombosis. Thromb Haemostas 1991; 65 (Suppl) 872
    PubMedSearch in Google Scholar
  • 19 Nurmohamed MT, Rosendaal FR, Buller HR. et al.: Low-molecular-weight heparin versus standard heparin in general and orthopedic surgery. Lancet 1992; 340: 152-156
    CrossrefPubMedSearch in Google Scholar
  • 20 Leyvraz PF, Bachmann F, Hoek J, Buller HR, Postel M, Samama M, Vandenbroek MD. Prevention of deep vein thrombosis after hip replacement: randomized comparison between unfractionated heparin and low molecular weight heparin. Br Med J 1991; 303: 543-548
    CrossrefPubMedSearch in Google Scholar
  • 21 Anderson DR, O'Brien B, Levine MN, Hirsh J. Comparison of the cost-effectiveness of LMWH and standard heparin for the prevention of DVT following total hip arthroplasty (THR). Blood 1992; (Suppl. 80) (01) 318a
    PubMedSearch in Google Scholar
  • 22 Melissari E, Das S, Kanthou C, Pemberton KD, Kakkar VV. The use of LMW heparin in treating thromboembolism during pregnancy and prevention of osteoporosis. Thromb Haemostas 1991; 65: 926 (abstr)
    PubMedSearch in Google Scholar