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Thromb Haemost 1992; 68(04): 388-391
DOI: 10.1055/s-0038-1646282
Original Article
Schattauer GmbH Stuttgart

Serum Osteocalcin as a Marker for Vitamin K-Status in Pregnant Women and Their Newborn Babies

Kon-Siong G Jie
1   The Department of Biochemistry, University of Limburg, Maastricht, The Netherlands
,
Karly Hamulyák
2   The Department of Hematology, University Hospital, Maastricht, The Netherlands
,
Birgit L M G Gijsbers
1   The Department of Biochemistry, University of Limburg, Maastricht, The Netherlands
,
Frans J M E Roumen
3   The Department of Obstetrics, St. Elisabeth Clinic, Heerlen, The Netherlands
,
Cees Vermeer
1   The Department of Biochemistry, University of Limburg, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 19 March 1992

Accepted after revision 23 April 1992

Publication Date:
04 July 2018 (online)

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Summary

Osteocalcin (bone Gla-protein) is a vitamin K-dependent protein synthesized by osteoblasts. Its hydroxylapatite binding capacity (HBC) is generally used to estimate the Gla-content of circulating osteocalcin. Here we have used the HBC of serum osteocalcin as a marker for the vitamin K-status in pregnant women and their offspring. For all cases investigated the HBC values in the cord samples were substantially lower than in the corresponding maternal ones. Babies from mothers who had been treated with vitamin K during the last 6 weeks prior to delivery, had significantly higher HBC values than those from a placebo group. The results presented in this paper are indicative for a generally occurring vitamin K deficiency in newborns. At delivery the HBC in untreated women was low as well. In both the placebo- and the vitamin K-group a good correlation was found between the HBC values in paired samples from mother and child. Whether the maternal HBC value may be used as a prenatal marker for estimating the fetal vitamin K-status remains to be seen.

 

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