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DOI: 10.1055/s-0038-1646292
Pharmacokinetic Properties of Recombinant Factor VIII Compared with a Monoclonally Purified Concentrate (Hemofil® M)
Publikationsverlauf
Received 30. Januar 1992
Accepted after revision 20. Mai 1992
Publikationsdatum:
26. Juli 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/199204/lookinside/thumbnails/10-1055-s-0038-1646292-1.jpg)
Summary
A recombinant FVIII preparation, Recombinate™, was compared with a high-purity plasma-derived concentrate, Hemofil® M, in 47 hemophilia A patients in a cross-over evaluation of pharmacokinetic properties. The recombinant material showed a significantly lower clearance, volume of distribution, and higher in vivo recovery, but a similar half-life to the plasma-based product.
In a comparison with reported data from other standard concentrates, the recombinant preparation exhibited potentially better pharmacokinetic properties in that its clearance was slower and its half-life was longer.
We conclude that the recombinant DNA method of preparation does not adversely affect the biological and pharmacological characteristics of the factor VIII molecule.
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