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Thromb Haemost 1991; 66(01): 044-048
DOI: 10.1055/s-0038-1646372
Review Article
Schattauer GmbH Stuttgart

Heparin or Heparan Sulfate - What is the Difference?

Ulf Lindahl
,
Lena Kjellén
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Publication Date:
25 July 2018 (online)

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  • References

  • 1 Jorpes J E, Gardell S. On heparin monosulfuric acid. J. Biol. Chem. 1948; 176: 267
    PubMedGoogle Scholar
  • 2 Rodén L. Highlights in the history of heparin. In: Heparin, chemical and biological properties, clinical applications.. Lane DA, Lindahl U. (eds) Edward Arnold, London, U. K.: 1989. pp 1-24
    Google Scholar
  • 3 Lindahl U. Biosynthesis of heparin and related polysaccharides. In: Heparin, chemical and biological properties, clinical applications.. Lane D A, Lindahl U. (eds) Edward Arnold, London, U. K.: 1989. pp 159-89
    Google Scholar
  • 4 Marcum JA, Rosenberg RD. The biochemistry, cell biology, and pathophysiology of anticoagulantly active heparin-like molecules of the vessel wall. In: Heparin, chemical and biological properties, clinical applications.. Lane DA, Lindahl U. (eds) Edward Arnold, London, U. K.: 1989. pp 275-294
    Google Scholar
  • 5 Lindahl U, Thunberg L, Bôckström G, Riesenfeld J, Nordling K, Björk I. Extension and structural variability of the antithrombin- binding sequence in heparin. J. Biol. Chem. 1984; 259: 12368-76
    PubMedGoogle Scholar
  • 6 Lindahl U, Feingold D S, Rodén L. Biosynthesis of heparin. Trends Biochem. Sci. 1986; 11: 221-25
    CrossrefPubMedGoogle Scholar
  • 7 Riesenfeld J, Höök M, Lindahl U. Biosynthesis of heparin. Concerted action of early polymer-modification reactions. J. Biol. Chem. 1982; 257: 421-25
    PubMedGoogle Scholar
  • 8 Kusche M, Lindahl U. Biosynthesis of heparin. O-Sulfation of D- glucuronic acid units. J. Biol. Chem. 1990; 265: 15403-09
    PubMedGoogle Scholar
  • 9 Kusche M, Bôckström G, Riesenfeld J, Petitou M, Choay J, Lindahl U. Biosynthesis of heparin. O-Sulfation of the antithrombin-binding region. J. Biol. Chem. 1988; 263: 15474-84
    PubMedGoogle Scholar
  • 10 Kusche M, Torri G, Casu B, Lindahl U. Biosynthesis of heparin. Availability of glucosaminyl 3-O-sulfation sites. J. Biol. Chem. 1990; 265: 7292-300
    PubMedGoogle Scholar
  • 11 Höök M, Lindahl U, Hallén A, Bôckström G. Biosynthesis of heparin. Studies on the microsomal sulfation process. J. Biol. Chem. 1975; 250: 6065-71
    PubMedGoogle Scholar
  • 12 Jacobsson I, Lindahl U, Jensen J W, Rodén L, Prihar H, Feingold D S. Biosynthesis of heparin. Substrate specificity of heparosan N- sulfate D-glucuronosyl 5-epimerase. J. Biol. Chem. 1984; 259: 1056-63
    PubMedGoogle Scholar
  • 13 Jacobsson I, Lindahl U. Biosynthesis of heparin. Concerted action of late polymer-modification reactions. J. Biol. Chem. 1980; 255: 5094-100
    PubMedGoogle Scholar
  • 14 Turnbull J E, Gallagher J T. Distribution of iduronate 2-sulphate residues in heparan sulphate. Evidence for an ordered polymeric structure. Biochem. J. 1991; 273: 553-59
    PubMedGoogle Scholar
  • 15 Gallagher J T, Walker A. Molecular distinctions between heparan sulphate and heparin. Analysis of sulphation patterns indicates that heparan sulphate and heparin are separate families of N-sulphated polysaccharides. Biochem. J. 1985; 230: 665-74
    PubMedGoogle Scholar
  • 16 Pejler G, Danielsson Å, Böjrk I, Lindahl U, Nader HB, Dietrich CP. Structure and antithrombin-binding properties of heparin isolated from the clams Anomalocardia brasiliana and Tivela mactroides. J. Biol. Chem. 1987; 262: 11413-21
    PubMedGoogle Scholar
  • 17 Kjellén L, Pettersson I, Lillhager P, Steen M-L, Pettersson U, Lehtonen P, Karlsson T, Ruoslahti E, Hellman L. Primary structure of a mouse mastocytoma proteoglycan core protein. Biochem. J. 1989; 263: 105-13
    CrossrefPubMedGoogle Scholar
  • 18 Kjellén L, Lindahl U. Proteoglycans - structures and interactions. Ann. Rev. Biochem. 1991 in press
    PubMedGoogle Scholar
  • 19 Pettersson I, Kusche M, Unger E, Wlad H, Nylund L, Lindahl U, Kjellén L. Biosynthesis of heparin. Purification of a 110 kDa mouse mastocytoma protein required for both glucosaminyl N-deacetylation and N-sulfation.. J. Biol. Chem. 1991 in press
    PubMedGoogle Scholar
  • 20 Brandan E, Hirschberg C B. Purification of rat liver N-heparan sulphate sulphotransferase. J. Biol. Chem. 1988; 263: 2417-22
    PubMedGoogle Scholar
  • 21 Marcum J A, Atha D H, Fritze L M S, Nawroth P, Stern D, Rosenberg R D. Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan. J. Biol. Chem. 1986; 261: 7507-17
    PubMedGoogle Scholar
  • 22 Pejler G, Bôckström G, Lindahl U, Paulsson M, Dziadek M, Fujiwara S, Timpl R. Structure and affinity for antithrombin of heparan sulfate chains derived from basement membrane proteoglycans. J. Biol. Chem. 1987; 262: 5036-43
    PubMedGoogle Scholar
  • 23 Lane D A, Pejler G, Flynn A M, Thompson E A, Lindahl U. Neutralization of heparin-related saccharides by histidine-rich glycoprotein and platelet factor 4. J. Biol. Chem. 1986; 261: 3980-86
    PubMedGoogle Scholar
  • 24 Horner A A. Rat heparan sulphates. A study of the antithrombin- binding properties of heparan sulphate chains from rat adipose tissue, brain, carcase, heart, intestine, kidneys, liver, lungs, skin and spleen. Biochem. J. 1990; 266: 553-59
    PubMedGoogle Scholar
  • 25 Kusche M, Oscarsson L-G, Reynertson R, Rodn L, Lindahl U. Biosynthesis of heparin. Enzymatic sulfation of pentasaccharides. J. Biol. Chem. 1991 in press
    PubMedGoogle Scholar
  • 26 Lindahl U, Kusche M, Lidholt K, Oscarsson L-G. Biosynthesis of heparin and heparan sulfate. Ann. NY Acad. Sci. 1989; 556: 36-50
    CrossrefPubMedGoogle Scholar