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Thromb Haemost 1991; 66(02): 218-221
DOI: 10.1055/s-0038-1646393
Review Article
Schattauer GmbH Stuttgart

Variable Effects of Radiological Contrast Media on Thrombus Growth in a Rabbit Jugular Vein Thrombosis Model

Marcel Levi
The Centre for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Centre, Amsterdam, The Netherlands
,
Bart J Biemond
The Centre for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Centre, Amsterdam, The Netherlands
,
Augueste Sturk
The Centre for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Centre, Amsterdam, The Netherlands
,
Jaap Hoek
The Centre for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Centre, Amsterdam, The Netherlands
,
Jan Wouter ten Cate
The Centre for Thrombosis, Haemostasis and Atherosclerosis Research, Academic Medical Centre, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received 24 July 1990

Accepted 19 February 1991

Publication Date:
25 July 2018 (online)

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Summary

We studied the effect of an ionic high osmolar contrast medium (Ioxitalamate), an ionic low osmolar contrast medium (Ioxaglate) and various nonionic low osmolar contrast media (Iopamidol, Iopromide and Iohexol) on thrombus growth in a rabbit jugular vein thrombosis model. Thrombus growth was determined by the accretion of 125I-labeled fibrinogen onto autologous preformed thrombi in rabbit jugular veins at various time-intervals from 15 min up to 10 h after infusion of the study solution.

The ionic low osmolar contrast medium markedly inhibited thrombus growth whereas all nonionic low osmolar contrast media promoted thrombus growth. The ionic high osmolar contrast medium inhibited thrombus growth, but less than the ionic low osmolar contrast medium. Within the group of nonionic contrast media, the Iopamidol associated promotion of thrombus growth was significantly higher than the Iopromide or Iohexol associated effects. The simultaneous administration of the apparently most potent thrombus growth promoting contrast medium (i.e. Iopamidol) and heparin resulted in complete abolishment of the increase in thrombus growth.

These results support the claims of prothrombotic properties of nonionic as compared to ionic contrast media and could explain the clinically encountered thromboembolic complications after the use of nonionic low osmolar contrast media.

 

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