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Thromb Haemost 1991; 66(06): 648-651
DOI: 10.1055/s-0038-1646479
Original Article
Schattauer GmbH Stuttgart

Influence on Platelet Function by Heparin in Men with Unstable Coronary Artery Disease

Ulf Berglund
The Division of Cardiology, Department of Internal Medicine, University Hospital, Linköping, Sweden
,
Lars Wallentin
The Division of Cardiology, Department of Internal Medicine, University Hospital, Linköping, Sweden
› Institutsangaben
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Publikationsverlauf

Received 16. Mai 1990

Accepted 18. Juni 1991

Publikationsdatum:
26. Juli 2018 (online)

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Summary

Ninetyseven men with unstable coronary artery disease (CAD), i.e. unstable angina or a non Q-wave myocardial infarction, entered a double-blind placebo-controlled study with heparin intravenously 30,000-40,000 U daily. Platelet function was evaluated as ex vivo aggregation toward collagen and ADP and as the platelet inhibitory effect of prostacyclin, before and after 5 days of treatment. Heparin increased aggregation induced by ADP 1 εM from 39.6 ± 3.1% to 52.1 ± 4.1% (p = 0.014) and reduced the inhibition of aggregation by prostacyclin 1.0 ng/ml from 59.6 ± 3.7% to 39.3 ± 5.6% (p <0.001). No changes occurred in the placebo group.

Thus, treatment with heparin enhances the platelet sensitivity to ADP and decreases the platelet inhibitory effect of prostacyclin in men with unstable CAD. Concomitant treatment with acetylsalicylic acid abolishes the increased reponse to ADP, but does not seem to influence the interaction between heparin and prostacyclin.

 

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