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Thromb Haemost 1989; 61(01): 117-121
DOI: 10.1055/s-0038-1646538
Original Article
Schattauer GmbH Stuttgart

Haemostatic Effects of Recombinant Human Erythropoietin in Chronic Haemodialysis Patients

Chris van Geet
The Centre for Thrombosis and Vascular Research and the Department of Nephrology, University of Leuven, Belgium
,
Didier Hauglustaine
The Centre for Thrombosis and Vascular Research and the Department of Nephrology, University of Leuven, Belgium
,
Luc Verresen
The Centre for Thrombosis and Vascular Research and the Department of Nephrology, University of Leuven, Belgium
,
Marleen Vanrusselt
The Centre for Thrombosis and Vascular Research and the Department of Nephrology, University of Leuven, Belgium
,
Jos Vermylen
The Centre for Thrombosis and Vascular Research and the Department of Nephrology, University of Leuven, Belgium
› Institutsangaben
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Publikationsverlauf

Received 16. Mai 1988

Accepted after revision 26. September 1988

Publikationsdatum:
24. Juli 2018 (online)

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Summary

Recombinant human erythropoietin was administered for up to 40 weeks to nine patients on chronic haemodialysis. From the third week of administration onwards, not only haemoglobin and haematocrit but also the platelet count rose, the latter, however, transiently. Subnormal platelet aggregation before therapy also improved transiently and in parallel with the erythropoietin dosage. The bleeding time normalized in almost all patients. There were no major side-effects. We conclude that recombinant erythropoietin improves haemostasis in chronic haemodialysis patients by increasing the haematocrit and in addition transiently enhances platelet number and function.

Key words

Recombinant human erythropoietin - Chronic haemodialysis patients - Bleeding time - Platelet
 

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