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Thromb Haemost 1989; 61(01): 127-130
DOI: 10.1055/s-0038-1646540
Original Article
Schattauer GmbH Stuttgart

Spontaneous Whole Blood Platelet Aggregation in Insulin-Dependent Diabetes Mellitus: An Evaluation in an Epidemiologic Study

Nam H Cho
1   The Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
,
Dorothy Becker
2   The Department of Endocrinology, Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
,
Janice S Dorman
1   The Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
,
Sidney Wolfson
3   The Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
,
Lewis H Kuller
1   The Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
,
Allan L Drash
2   The Department of Endocrinology, Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA
,
William F Follansbee
4   The Exercise Physiology and Nuclear Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
,
Sherryl F Kelsey
1   The Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
,
Trevor J Orchard
1   The Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
› Author Affiliations
Further Information

Publication History

Received 25 April 1988

Accepted after revision 30 September 1988

Publication Date:
24 July 2018 (online)

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Summary

Spontaneous whole blood platelet aggregation (SWBPA) was examined in a case-control study, comparing a consecutive series of IDDM subjects (n = 30) to age, and sex matched controls. Subjects were free of platelet altering medications. Platelet aggregation was measured by the percent fall in single platelet count after 15 minutes of both shaking (SK) and magnetic stirring (ST). IDDM subjects showed a significantly greater percent fall in SK (x = 12.1) and ST (x = 34.0) compared to controls (SK x = 8.4, p <0.01; ST x = 24.3, p <0.05). Long-term repeat testing on 15 subjects (diabetics and non-diabetics) up to 4 months apart showed a correlation of 0.7 for SK, p <0.01 but only 0.4 for ST. In a further series of IDDM subjects (n = 176) those with macrovascular disease (n = 27) showed significantly greater percent fall in SK (p<0.05), and ST (p<0.05).

We conclude that SWBPA is a simple useful epidemiological technique (shaking being more repeatable than stirring) which relates to both diabetes and macrovascular disease.

Key words

Platelet aggregation - Diabetes - Macrovascular disease
 

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