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Thromb Haemost 1989; 61(02): 175-177
DOI: 10.1055/s-0038-1646554
Original Article
Schattauer GmbH Stuttgart

Impaired Fibrinolysis as an Essential Contribution to Thrombosis in Patients with Lupus Anticoagulant

D A Tsakiris
1   The Coagulation and Fibrinolysis Laboratory, Kantonsspital Basel, Switzerland
,
G A Marbet
1   The Coagulation and Fibrinolysis Laboratory, Kantonsspital Basel, Switzerland
,
P E Makris
2   The A’Medical Propaedeutic Department, Aristotelian University of Thessaloniki, Greece
,
L Settas
2   The A’Medical Propaedeutic Department, Aristotelian University of Thessaloniki, Greece
,
F Duckert
1   The Coagulation and Fibrinolysis Laboratory, Kantonsspital Basel, Switzerland
› Author Affiliations
Further Information

Publication History

Received 15 June 1988

Accepted after revision 26 September 1988

Publication Date:
30 June 2018 (online)

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Summary

Lupus anticoagulants (LA) are IgG or IgM antibodies against phospholipids which in vivo represent an important thrombophilic factor despite their in vitro anticoagulant activity. We investigated the fibrinolytic system of 20 patients with connective tissue disease and positive LA, compared to a control group of 24 age- and disease-matched patients without LA. There was no statistically significant difference of alpha2-antiplasmin, plasminogen, fibrinogen, t-PA activity, D-dimers and heparin cofactor II, between the two groups. Although t-PA was uniformly low in both groups, plasminogen activator inhibitor activity (PAI) was significantly higher in LA cases (p <0.001). Increased PAI levels represent an inhibitory factor of the fibrinolytic defense mechanism, which together with other functional deviations may contribute to the thrombophilic tendency of LA patients.

Keywords

Lupus anticoagulant - Fibrinolysis - Plasminogen activator inhibitor - Tissue plasminogen activator - Alpha2-antiplasmin - Plasminogen - D-dimers - Heparin cofactor II - Antithrombin III - C4 complement component
 

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