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Thromb Haemost 1978; 39(01): 032-038
DOI: 10.1055/s-0038-1646651
Original Article
Schattauer GmbH Stuttgart

Catabolism of Fibrinogen in Pregnant Rabbits before and after Delivery

Ingo Mahn
Division of Clinical Immunology and Blood Transfusion, Central Division of the Department of Nuclear Research, and the Department of Medicine, Justus-Liebig-Universität, Giessen, West-Germany
,
Richard-Mathias Moeller
Division of Clinical Immunology and Blood Transfusion, Central Division of the Department of Nuclear Research, and the Department of Medicine, Justus-Liebig-Universität, Giessen, West-Germany
,
Gert Müller-Berghaus
Division of Clinical Immunology and Blood Transfusion, Central Division of the Department of Nuclear Research, and the Department of Medicine, Justus-Liebig-Universität, Giessen, West-Germany
› Author Affiliations
Further Information

Publication History

Received 13 April 1977

Accepted 24 June 1977

Publication Date:
12 July 2018 (online)

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Summary

16 nón-pregnant female and 19 pregnant rabbits were injected with purified rabbit 125I-fibrinogen in order to study the catabolism of fibrinogen before and after delivery. The half-life time (T ½) of the clottable 125I-radioactivity in pregnant rabbits during the last third of gestation was 27.3 ± 5.3 hr in comparison to 54.4 ± 3.7 hr in non-pregnant rabbits. After delivery, T ½ returned to normal values of 47.9 ± 10.9 hr. The fractional catabolic rate (FCR) of the clottable 125I-radioactivity was 67.1% × d−1 ± 8.6 before and 41.6% × d−1 after delivery whereas FCR in non-pregnant rabbits amounted to 44.7% × d−1 ± 4.8. These figures demonstrate a pronounced increase in fibrinogen catabolism during the last third of gestation in pregnant rabbits and a normalization immediately after delivery. Although in pregnant rabbits the elimination of fibrinogen from the circulating blood was pronouncedly increased, the plasma fibrinogen concentration did not change. Only after delivery did the fibrinogen concentration increase when the fibrinogen catabolism had already normalized.

 

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