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Thromb Haemost 1978; 39(01): 069-073
DOI: 10.1055/s-0038-1646656
Original Article
Schattauer GmbH Stuttgart

Effect of Orthostatic Changes on Urokinase Excretion

Gilbert M Wilcox
*   The Department of Medicine, Mary Hitchcock Memorial Hospital, Dartmouth Medical School, Hanover, New Hampshire 03755, U.S.A.
,
Valdemar Hial
**   Departamento do Bioquimica, Faculdade do Medicina do Triangula Mineiro, 38.100-Uberaba-M. G., Brasil
,
David Horwitz
***   Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.
,
John J Pisano
****   Section on Physiological Chemistry, Laboratory of Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.
,
Harry R Keiser
***   Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 08 March 1997

Accepted 26 May 1997

Publication Date:
12 July 2018 (online)

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Summary

The effects of orthostatic changes on the excretion of urokinase were studied in healthy normal volunteers. Urokinase excretion rose (average +69%) significantly (p<.005) while urine volume fell (average–59%) significantly (p <.001) after the subjects had been standing. There was no difference between men and women nor was there an apparent diurnal variation in urokinase excretion of recumbent subjects. A relationship between urokinase excretion and sympathetic nervous system activity is suggested.

 
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