Download PDF
Thromb Haemost 1978; 39(01): 069-073
DOI: 10.1055/s-0038-1646656
Original Article
Schattauer GmbH Stuttgart

Effect of Orthostatic Changes on Urokinase Excretion

Gilbert M Wilcox
*   The Department of Medicine, Mary Hitchcock Memorial Hospital, Dartmouth Medical School, Hanover, New Hampshire 03755, U.S.A.
,
Valdemar Hial
**   Departamento do Bioquimica, Faculdade do Medicina do Triangula Mineiro, 38.100-Uberaba-M. G., Brasil
,
David Horwitz
***   Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.
,
John J Pisano
****   Section on Physiological Chemistry, Laboratory of Chemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.
,
Harry R Keiser
***   Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20014, U.S.A.
› Author Affiliations
Further Information

Publication History

Received 08 March 1997

Accepted 26 May 1997

Publication Date:
12 July 2018 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

The effects of orthostatic changes on the excretion of urokinase were studied in healthy normal volunteers. Urokinase excretion rose (average +69%) significantly (p<.005) while urine volume fell (average–59%) significantly (p <.001) after the subjects had been standing. There was no difference between men and women nor was there an apparent diurnal variation in urokinase excretion of recumbent subjects. A relationship between urokinase excretion and sympathetic nervous system activity is suggested.

 
  • 1 Bernik MB, White WF, Oller EP, Kwaan HC. 1974; Immunologic identity of plasminogen activator in human urine, heart, blood vessels and tissue culture. Journal of Laboratory and Clinical Medicine 84: 546
    PubMedGoogle Scholar
  • 2 Biggs R, MacFarlane RG, Pilling J. 1947; Observations on fibrinolysis. Experimental activity produced by exercise or adrenaline. Lancet I: 402
    PubMedGoogle Scholar
  • 3 Cash JD. 1966; Effect of moderate exercise on the fibrinolytic system in normal young men and women. British Medical Journal 2: 502
    CrossrefPubMedGoogle Scholar
  • 4 Celander DR, Guest MM. 1960; The biochemistry and physiology of urokinase. American Journal of Cardiology 6: 409
    CrossrefPubMedGoogle Scholar
  • 5 Duckert F. 1968. In: Enzymes in Urine and Kidney. Dubach UC. (ed.) Williams & Wilkins, Baltimore; Maryland: 237 264
  • 6 Fearnley GR, Balmforth G, Fearnley E. 1957; Evidence of a diurnal fibrinolytic rhythm. With a simple method of measuring natural fibrinolysis. Clinical Science 16: 645
    PubMedGoogle Scholar
  • 7 Holemans R, McConnell D, Johnston JG. 1966; Urokinase levels in urine after nicotinic acid injection. Thrombosis et Diathesis Haemorrhagica 15: 192
    PubMedGoogle Scholar
  • 8 Imanari T, Wilcox GM, Pisano JJ. 1976; Sensitive radiochemical esterolytic assay for urokinase. Clinica Chimica Acta 71: 267
    CrossrefPubMedGoogle Scholar
  • 9 Karkl NT. 1956; The urinary excretion of noradrenaline and adrenaline in different age groups, its diurnal viriation and the effect of muscular work on it. Acta Physiologica Scandinavia 36: 07 Suppl (Suppl. 132)
    PubMedGoogle Scholar
  • 10 Kucinski CS, Fletcher AP, Sherry S. 1968; Effect of urokinase anti-serum on plasminogen activators. Demonstration of immunologic dissimilarity between plasma plasminogen activator and urokinase. Journal of Clinical Investigation 47: 1238
    CrossrefPubMedGoogle Scholar
  • 11 Macfarlane RG, Pilling J. 1947; Fibrinolytic activity of normal urine. Nature 159: 779
    PubMedGoogle Scholar
  • 12 Rosing DR, Brakman P, Redwood DR, Goldstein RE, Beiser GD, Astrup T, Epstein SE. 1970; Blood fibrinolytic activity in man. Diurnal variation and the response to varying intensities of exercise. Circulation Research 27: 171
    CrossrefPubMedGoogle Scholar
  • 13 Smyrniotis FE, Fletcher AP, Alkjaersig N, Sherry S. 1959; Urokinase excretion in health and its alteration in certain disease states. Thrombosis et Diathesis Haemorrhagica 3: 257
    PubMedGoogle Scholar
  • 14 Sobel GW, Mohler SR, Jones NW, Dowdy ABC, Guest MM. 1952; Urokinase: An activator of plasma profibrinolysin extracted from urine. American Journal of Physiology 171: 768
    PubMedGoogle Scholar
  • 15 Sudin T. 1958; The effect of body posture on the urinary excretion of adrenaline and noradrenaline. Acta Medica Scandivia 161: 05 Suppl (Suppl. 336)
    PubMedGoogle Scholar
  • 16 von Kaulla KN, Riggenbach N. 1960; Urokinase excretion in man. A method of determination and consideration of its significance. Thrombosis et Diathesis Diathermia Haemorrhagica 5: 162
    PubMedGoogle Scholar