Thrombogenic Effects of some Concentrates of Coagulation Factors: a Possible Role of Contaminating Endotoxin

Thromb Haemost 1978; 39(02): 533-534
DOI: 10.1055/s-0038-1646718

Letters to the Editor

Schattauer GmbH Stuttgart

D Fumarola

Chair of Microbiology, Bari University School of Medicine, 70124-Bari, Italy

References
1 Davey RJ, Shashaty GG, Rath CE. 1976 Acute coagulopathy following infusion of Prothrombin Complex Concentrate. American Journal of Medicine. 60. 719
2 Fumarola D, Jirillo E. 1977; Limulus test, parenteral drugs and biological products: an approach. Developments in biological standardization 34: 97
3 Fumarola D, Marcuccio L, Monno R, Panaro A, Longo-PAPADIA L, Papadia J. 1976; Sulla verifica della contaminazione con endotossine batteriche in emoderivati utilizzati nell’area coagulativa: osservazioni col Limulus test. Giornale di Batteriologia, Virologia e Immunologia 59: 260
4 Messmore HL, Fareed J, Silberman S, Weinstein R. 1975; The thrombogen city of Prothrombin Complex Concentrate and the protective effect of heparin in humans and animals. Blood 46: 1003
5 Semeraro N. 1976; Endotoxin and haemostasis. Acta Clinica Belgica 31: 377
6 Semeraro N, Fumarola D, Telesforo P, Vermylen J. 1976; Platelet-endotoxin interaction: a review. Bollettino delhlstituto Sieroterapico Milanese 55: 511
7 Semeraro N, Fumarola D, Mertens F, Vermylen J. 1978 Evidence that endotoxin enhance the factor-X activator activity of washed human platelets. British Journal of Haematology (in press)
8 White GC, Roberts HR, Kingdon HS, Lundblad RL. 1977; Prothrombin complex concentrates. Potentially thrombogenic materials and clues to the mechanism of thrombosis in vivo. Blood 49: 159