Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1978; 39(03): 683-688DOI: 10.1055/s-0038-1646743 Original Article Schattauer GmbH Stuttgart The Effects of an Increase in Endogenous Oestrogen on the Haemostatic Mechanism J L Toy 1 The University Department of Medicine, The General Infirmary, Leeds LSI 3EX, England , J A Davies 1 The University Department of Medicine, The General Infirmary, Leeds LSI 3EX, England , K W Hancock 1 The University Department of Medicine, The General Infirmary, Leeds LSI 3EX, England , G P McNicol 1 The University Department of Medicine, The General Infirmary, Leeds LSI 3EX, England › Author Affiliations Recommend Article Abstract PDF Download Buy Article Summary The effects on the haemostatic mechanism of rises in circulating human oestrogen in a group of women being treated for infertility with pituitary hormones were studied. Despite large but brief rises in oestrogen levels no changes were found. PDF (535 kb) References References 1 Alkjaersig N, Fletcher AP, Sherry S. 1969; The mechanism of clot dissolution BY plasmin. Journal of Clinical Investigation 38: 1086 2 Amris CJ, Starup J. 1967; The coagulation mechanism in oral contraception. Acta obstetricia et gynaecologica Scandinavica 46: 78 3 Biggs R. 1976. Human blood coagulation, haemostasis and thrombosis. Blackwell Scientific Publications; Oxford: 726-721 4 Blix S. 1961; Studies on the fibrinolytic system in the euglobulin in fraction of human plasma. Scandinavian Journal of Clinical and Laboratory Investigation 13 Suppl (Suppl. 58) 3 5 Bonnar J, Mcnicol GP, Douglas AS. 1969; Fibrinolytic enzyme system and pregnancy. British Medical Journal 3: 287 6 Born GVR, Cross MJ. 1963; The aggregation of blood platelets. Journal of Physiology (London) 168: 178 7 Bowie WEJ, Owen CA, Thompson JH, Didisheim P. 1969; Platelet adhesiveness in von Willebrand’s disease. American Journal of Clinical Pathology 52: 69 8 Breckenridge RT, Ratnoff OD. 1962; Studies on the nature of the circulating anticoagulant directed against anti-haemophilic factors. Blood 20: 137 9 Davies T, Lederer DA, Davies JA, Mcnicol GP. 1974; The effect of aspirin on exercise-induced changes in platelet function and blood coagulation. Thrombosis Research 5: 69 10 Davies T, Fieldhouse G, Mcnicol GP. 1976; The effects of therapy with oestriol succinate and ethinyl oestradiol on the haemostatic mechanism in post-menopausal women. Thrombosis and Haemostasis 35: 403 11 Donayre J, Pincus G. 1965; Effects of Enovid on blood clotting factors. Metabolism 14: 418 12 Hakim CA, Elder MG, Hawkins DF. 1969; Plasma factor IX levels in patients given hexoestriol or stilboestrol to suppress lactation. British Medical Journal 4: 82 13 Hedlin AM. 1975; The effect of oral contraceptive oestrogen on blood coagulation and fibrinolysis. Thrombosis et Diathesis Haemorrhagica 33: 370 14 Hougie C, Rutherford RN, Banks AL, Coburn WA. 1965; Effect of a progestin-estrogen oral contraceptive on blood clotting factors. Metabolism 14: 411 15 Howie PW, Mallinson AC, Prentice CRM, Horne CHW, Mcnicol GP. 1970; Effect of combined oestrogen-progestogen oral contraceptives, oestrogen and progestogen on antiplasmin and antithrombin activity. Lancet II: 1329 16 Howie PW, Prentice CRM, Mcnicol GP. 1973; A method of anti-thrombin estimation using plasma defibrinated with ancrod. British Journal of Haematology 25: 101 17 Langdell RD, Wagner RH, Brinkhous WF. 1953; Effect of anti-haemophilic factor on one-stage clotting tests. Journal of Laboratory and Clinical Medicine 41: 637 18 Mcnicol GP, Gale SB, Douglas AS. 1963; In vitro and in vivo studies of a preparation of urokinase. British Medical Jornal I: 909 19 Medical Research Council. 1967; Risk of thromboembolic disease in women taking oral contraceptives. A preliminary communication by a sub-committee. British Medical Journal 2: 355 20 Mielke CH, Kaneshiro MM, Maher IA, Weiner JM, Rapaport SI. 1969; The standardised normal Ivy bleeding time and its prolongation by aspirin. Blood 34: 204 21 Miller SP, Lee SL, Ritz N. 1965; Progestin-estrogen (SC II, 800) therapy and the haemostatic mechanisms – a controlled study. Metabolism 14: 398 22 Nilsson IM, Kullander S. 1967; Coagulation and fibrinolytic studies during use of progestagens. Acta obstetricia et gynaecologica Scandinavica 46: 78 23 Notelovitz M. 1975; The effect of natural oestrogens on coagulation. South African Medical Journal 49: 101 24 Notelovitz M, Greig HBW. 1976; Natural oestrogen and anti-thrombin III activity in postmenopausal women. Journal of Reproductive Medicine 16: 87 25 Pechet L, Alexander B. 1961; Increased clotting factors in pregnancy. New England Journal of Medicine 265: 1093 26 Peterson RA, Krull PE, Finley P, Ettinger MG. 1970; Changes in anti-thrombin III and plasminogen by oral contraceptives. American Journal of Clinical Pathology 53: 468 27 Poller L. 1973. Oral contraception, blood coagulation and platelets. In: Poller L. (ed) Recent advances in blood coagulation. Churchill; London: 181 28 Poller L, Thomson JM. 1966; Clotting factors during oral contraception. further report. British Medical Journal 2: 23 29 Poller L, Thomson JM, Coope J. 1977; Conjugated equine oestrogens and blood clotting. a follow-up report. British Medical Journal I: 935 30 Quick A, Stanley-Brown M, Bancroft FW. 1935; A study of the coagulation defect in haemophilia and in jaundice. American Journal of Medical Science 190: 501 31 Ratnoff OD, Colopy JE, Pritchard JA. 1954; The blood clotting mechanism during normal parturition. Journal of Laboratory and Clinical Medicine 44: 408 32 Ratnoff OD, Menzie C. 1951; A new method for determination of fibrinogen in small samplesof plasma. Journal of Laboratory and Clinical Medicine 37: 316 33 Talbert LM, Langdell RD. 1964; Normal values of certain factors in the blood clotting mechanism in pregnancy. American Journal of Obstetrics and Gynecology 90: 44 34 Vessey MP, Doll R. 1969; Investigation of relation between use of oral contraceptives and thromboembolic disease. A further report. British Medical Journal 2: 651 35 Von Kaulla E, Von Kaulla KN. 1970; Oral contraceptives and low antithrombin III activity. Lancet I: 36 36 Ygge J, Brody S, Korsan-Bengtsen K, Nillson L. 1969; Changes in blood coagulation and fibrinolysis in women receiving oral contraceptives. American Journal of Obstetrics and Gynecology 104: 87
