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Thromb Haemost 1978; 39(03): 701-706
DOI: 10.1055/s-0038-1646746
Original Article
Schattauer GmbH Stuttgart

Blood Platelets as a Possible Source of Creatine Kinase in Rat Plasma and Serum

Sachiko Shibata
1   Radioisotope Research Laboratory and Department of Physiological Chemistry, School of Pharmaceutical Sciences, Kitasato University, Tokyo 108, Japan
,
Bonro Kobayashi
1   Radioisotope Research Laboratory and Department of Physiological Chemistry, School of Pharmaceutical Sciences, Kitasato University, Tokyo 108, Japan
› Author Affiliations
Further Information

Publication History

Received 18 February 1977

Accepted 05 September 1977

Publication Date:
12 July 2018 (online)

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Summary

The creatine kinase (CK) activity in rat plasma was found to be correlated with that in serum or platelets. Rat serum contained higher activity not only of CK but also of lactate dehydrogenase than the corresponding plasma. The plasma CK activity decreased with increasing age of rats. Only the brain-type isoenzyme of CK was found in plasma, serum and platelets. Contamination of brain-type with muscle-type isoenzyme was detected in rather exceptional cases in which the activity was high among old rats. These results suggest the possible contribution of blood platelets to the CK activity of circulating plasma as well as to the activity in serum in rats.

 

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