Increase of the Sialic Acid-Rich Variants of the Bβ-and γ-Chains of Fibrinogen Zurich II

Summary

The abnormally high sialic acid-content of fibrinogen Zurich II could be attributed to the presence of a higher proportion of the sialic acid-rich L variant of both the γ and Bβ- polypeptide chains of fibrinogen Zurich II as compared to normal fibrinogen.

• References

• 1 Aminoff D. 1961; Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochemical Journal 81: 384
• 2 Chandrasekhar N, Warren L, Osbahr AJ, Laki K. 1962; Role of sialic acid in fibrinogen. Biochimica et biophysica acta 63: 337
• 3 Funk C, Straub PW. 1970; Hereditary abnormality of fibrin monomer aggregation (Fibrinogen Zurich II). European Journal of Clinical Investigation 1: 131
• 4 Gaffney PJ. 1972; Localisation of carbohydrate in the subunits of human fibrinogen and its plasmin induced fragments. Biochimica et biophysica acta 263: 453
• 5 Gati WP, Straub PW. 1978; Separation of both the p- and the y-polypeptide chains of human fibrinogen into two main types which differ in sialic acid content. Journal of Biological Chemistry 253: 1315
• 6 Martinez J, Palascak JE, Peters CL. Functional and metabolic studies of human asialofibrinogen. Abstract V^th Congress of the International Society. Thrombosis and Hemostasis. Paris: 21.07.1975: 26
• 7 Mester L, Szabados L. 1968; Differences constitutionnelles dans les fragments glucidiques d’un fibrinogène humain anormal. Comptes Rendus 266: 34
• 8 Mester L, Szabados L. 1970; Structure défectueuse et biosynthése des fractions glucidiques dans les variantes pathologiques du fibrinogéne. Nouvelle Revue FranÇaise d’Hématologie 10: 679
• 9 Mosesson MW, Alkjaersig N, Sweet B, Sherry S. 1967; Human fibrinogen of relatively high solubility. Comparative biophysical, biochemical and biological studies with fibrinogen of lower solubility. Biochemistry 6: 3279
• 10 Murano G, Wiman B, Blombäck M, Blombäck B. 1971; Preparation and isolation of the S- carboxymethyl derivative chains of human fibrinogen. FEBS Letters 14: 37
• 11 Pepper DS, Gaffney PJ, Blume HD. 1974; The distribution of carbohydrate in the plasmin resistant core fragments (D, E) of human fibrinogen. Biochimica et biophysica acta 365: 203
• 12 Pizzo SV, Schwartz ML, Hill RL, Mckee PA. 1972; ITie effect of plasmin on the subunit structure of human fibrinogen. Journal of biological chemistry 247: 636
• 13 Sherman LA, Mosesson MW, Sherry S. 1969; Isolation and characterization of the clottable low molecular weight fibrinogen derived by limited plasmin hydrolysis of human fraction I- 4. Biochemistry 8: 1515
• 14 Warren L. 1959; The thiobarbituric acid assay of sialic acids. Journal of biological chemistry 234: 1971