Thromb Haemost 1989; 62(02): 715-717
DOI: 10.1055/s-0038-1646889
Original Article
Schattauer GmbH Stuttgart

Von Willebrand Factor Multimer Patterns in Pregnancy-Induced Hypertension

B Brenner
The Hematology Institute, Ichilov Hospital, Tel-Aviv Medical Center and Sackler School of Medicine, Tel-Aviv University, Haifa, Israel
,
E Zwang
The Hematology Institute, Ichilov Hospital, Tel-Aviv Medical Center and Sackler School of Medicine, Tel-Aviv University, Haifa, Israel
,
M Bronshtein
*   The Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel
,
U Seligsohn
The Hematology Institute, Ichilov Hospital, Tel-Aviv Medical Center and Sackler School of Medicine, Tel-Aviv University, Haifa, Israel
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 21. Juli 1987

Accepted after revision 12. April 1989

Publikationsdatum:
30. Juni 2018 (online)

Summary

Microangiopathy and disseminated platelet aggregation have been reported in thrombotic thrombocytopenic purpura (TIP) and pregnancy-induced hypertension (PIH). Since unusually large von Willebrand factor (vWF) multimers have been implicated in the evolvement of TTP, we analyzed factor VIII/vWF parameters in patients with PIH. Mean vWF: Ag level was significantly higher in 27 patients with PIH as compared to 20 matched healthy pregnant women (358 ± 160 u/dl vs. 274 ± 125 u/dl, p < 0.05). Moreover, plasma vWF: Ag levels and the ratio of vWF: Ag to factor VIII were found to be linearly correlated to the severity of PIH. In contrast, no significant differences in mean levels of factor VIII and ristocetin cofactor were observed between these groups. Crossed immunoelectrophoresis of vWF revealed a higher incidence of a pre-peak and an increased migration index in the PIH group as compared to the control group (60% vs. 44% and 1.27 ± 0.26 vs. 1.19 ± 0.18, p < 0.01 respectively). Analysis of plasma vWF multimer patterns by 1.4% agarose electrophoresis in 0.1% SDS revealed excessive amounts of large, medium and small size multimers in the PIH patients. Conceivably, the quantitative changes in vWF multimers reflect endothelial injury and may play a role in the microangiopathy observed in PIH.

 
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