Subscribe to RSS
DOI: 10.1055/s-0038-1646995
The Influence of Adrenaline on Gender Difference in Adenosine Diphosphate-Induced Aggregation of Platelets in the Rat
Publication History
Received 11 January 1988
Accepted after revision 09 August 1988
Publication Date:
30 June 2018 (online)
Summary
The role of adrenaline on the inhibitory effects of physiological levels of oestradiol on ADP-induced intravascular aggregation has been studied. Platelets from pro-oestrous female rats aggregated less than those from dioestrous and male rats. Following adrenalectomy, there was no longer any difference(s) in the aggregability of the platelets to ADP in any of the rats. Adrenaline infusion (20 mg kg−1 hr−1) restored platelet aggregation to preadrenalectomy levels in pro-oestrous rate. Measurement of spontaneous fibrinolytic activity of the plasma showed highest value in pro-oestrous rats. Adrenalectomy reduced, while adrenaline infusion increased the fibrinolytic activity. The results suggest that the inhibitory effects of oestradiol on intravascular aggregation are dependent on endogenous adrenaline possibly working through the fibrinolytic pathway.
-
References
- 1 Oliver MF. Sex differences in pathogenesis and treatment occlusive arterial disease. Proc Coll Phys London McDonald L. (ed) 1959. pp 124-132
- 2 Kannell WB, Hjortland MC, McNamara PM, Gordon T. Menopause and the risk of cardiovascular disease. The Framingham study. Ann Intern Med 1976; 85: 447-452
- 3 Johnson M, Ramey E, Ramwell PN. Androgen-mediated sensitivity in platelet aggregation. Am J Phvsiol 1977; 232 H 371-377
- 4 Emms H, Lewis GP. Sex and hormonal influences on platelet sensitivity and coagulation in the rat. Br J Pharmacol 1985; 86: 557-563
- 5 Oyekan AO, Botting JH. A minimally invasive technique for the study of intravascular platelet aggregation in anaesthetized rats. J Pharmacol Methods 1986; 15: 271-277
- 6 Penhos JC, Montalbert-Smith M, Rabbani F, Ramey ER, Ramwell PW. Effects of corticosteroids on arachidonate. Prostaglandins 1979; 18: 697-706
- 7 Orchard MA, Botting JH. The influence of sex hormones on rat platelet sensitivity to adenosine diphosphate. Thromb Haemostas 1981; 46: 496-499
- 8 Vogt M. Inhibition by hexoestrol of adrenocortical secretion in the rat. J Physiol (London) 1954; 130: 601-614
- 9 Kitay JI. Pituitary adrenal function in the rat after gonadectomv and gonadal hormone replacement. Endocrinology 1963; 93: 253-260
- 10 Long A, Evans HA. The oestrous cycle in the rat and its associated phenomena. Memoirs. University of California Press 1922; 16: 1-4
- 11 Nilsson IM, Hedner U, Pandolfi M. The measurement of fibrinolytic activities. In: Fibrinolytics and Antifibrinolytics (Handbook of Experimental Pharmacology: New Series, V. 46) Springer-Verlag; Berlin: 1978
- 12 Dutcher RL, Collins WE, Fugo NW. Plasma concentrations of LH, FSH. prolactin, progesterone and 17B oestradiol. Endocrinology 1974 94: 1704-1708
- 13 Uzunova A, Ramey ER, Ramwell PW. Effect of testosterone, sex and age on experimentally-induced arterial thrombosis. Nature 1976; 261: 712-713
- 14 Poller L, Priest CM, Thomson JM. Platelet aggregation during oral contraception. Br Med J 1969; 4: 273-274
- 15 Spratto GR, Miller JW. An investigation of the mechanism by which oestradiol-17B elevates epinephrine content of the rat uterus. J Pharmacol Exp Ther 1968; 161: 07-13
- 16 Desnoyers PC. Indirect fibrinolytic agents. In: Fibrinolytics and Antifibrinolvtics (Handbook of Experimental Pharmacology: New Series, V. 46) Springer-Verlag; Berlin: 1978
- 17 Ovekan AO. Mechanisms of hormone effects on intravascular aggregability in rats. Ph. D. Thesis University of London; 1986
- 18 Boyle FC, Ohia SE. Changes in catecholamine inhibitory effects in the rat isolated uterus induced by ovariectomy and cyclooxygenase inhibition. Br Pharmacol Soc Proc 1984; C 78
- 19 Hussaini I, Moore PK. Fibrinolytic activity of Prostanoids in the rat. Br J Pharmacol 1985; 86: 813 pp