Classification of Antithrombin III Deficiencies Has a New Tower of Babel Been Built?

• References

• 1 Hultin MB, McKay J, Abildgaard U. Antithrombin Oslo: Type 1b classification of the first reported antithrombin-deticient family, with a review of hereditary antithrombin variants. Thromb Haemostas 1988; 59: 468-473
• 2 Sas G, Peto I, Banhegyi D, Blasko G, Domjdn G. Heterogeneity of the “classical” antithrombin III deficiency. Thromb Haemostas 1980; 43: 133-136
• 3 Sas G. Defects in serine protease inhibitors. Thromb Haemostas 1987; 58: 248 Abstr
• 4 Bock SC, Prochownik EV. Molecular genetic survey of L6 kindreds with hereditary antithrombin III deficiency. Blood 1987; 70: 1273-1278
• 5 Sas G, Blasko G, Bonhegyi D, JAke J, Pelos LA. Abnormal antithrombin III (Antithrombin III “Budapest”) as a cause of a familial thrombophilia. Thromb Diathes Haemorrh 1974; 32: 105-115
• 6 Nagy I, Losonczy H, Szaksz I, Temesi C, Hergert K. An analysis of clinical and laboratory data in patients with congenital antithrombin III (AT III) deficiency. Acta Med Hung 1979; 36: 53-60
• 7 SØrensen PJ, Dyerberg J, Stoffersen E, Krog h, Jensen M. Familial functional antithrombin III deficiency. Scand J Haematol 1980; 24: 105-109
• 8 Sorensen PJ, Sas G, Peto I, Blasko G, Kremmer T, Samu A. Distinction of two pathologic antithrombin III molecules: antithrombin III “Aalborg” and antithrombin III “Budapest”. Thromb Res 1982; 26: 2l1-212
• 9 Sas G. Hereditary antithrombin III deficiency: biochemical aspects. Haematologia 1984; 7: 81-86
• 10 Leone G, De Stefano V, Di Donfrancesco A, Ferrelli R, Tlaisci G, Bizzi B. Antithrombin III Pescara: a defective AT III variant with no alterations of plasma crossed immunoelectrophoresis, but with an abnormal crossed immono-electrofocusing pattern. Br J Haematol 1987; 65: 187-191
• 11 Bock SC, Harris JF, Schwartz CE, Ward JH, Hershgold EJ, Skolnick MH. Hereditary thrombosis in a Utah kindred is caused by a dysfunctional antithrombin III gene. Am J Hum Genet 1985; 37: 32-41
• 12 Sas G. Clinical significance and laboratory diagnosis of antithrombin III deficiencies. In: Biology of Antithrombins, Sas G (ed). CRC Press, Inc., Boca Raton in press