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Thromb Haemost 1988; 60(02): 199-204
DOI: 10.1055/s-0038-1647029
Original Article
Schattauer GmbH Stuttgart

Changes in Factor VIII Proteins After Cardiopulmonary Bypass in Man Suggest Endothelial Damage

D K Jones
1   The Department of Respiratory Physiology, Papworth Hospital, Cambridge, England
,
R Luddington
3   The Department of Clinical Haematology, Addenbrookes Hospital, Cambridge, England
,
T W Higenbottam
1   The Department of Respiratory Physiology, Papworth Hospital, Cambridge, England
,
J Scott
1   The Department of Respiratory Physiology, Papworth Hospital, Cambridge, England
,
N Cavarocchi
2   The Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, England
,
D Reardon
3   The Department of Clinical Haematology, Addenbrookes Hospital, Cambridge, England
,
J Calvin
4   The Department of Biochemistry, Addenbrookes Hospital, Cambridge, England
,
J Wallwork
2   The Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, England
› Author Affiliations
Further Information

Publication History

Received 25 November 1987

Accepted after revision 18 May 1988

Publication Date:
28 June 2018 (online)

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Summary

16 patients undergoing coronary artery bypass grafting using cardiopulmonary bypass (CPB) had blood samples taken at various times before, during and up to 1 week after surgery for estimation of beta-thromboglobulin (BTG), alpha- 1-antichymo- trypsin (ACT), factor VIII procoagulant protein (VIII:C), von Willebrand factor antigen (vWF:Ag) and ristocetin co-factor (vWFiRiCoF). vWF:Ag and vWF:RiCoF rose during and following surgery in a different manner to ACT. At 1 week there was a significantly disproportionate rise in vWF: Ag compared to vWFiRiCoF which suggested a degree of pulmonary endothelial damage.

Prostacyclin, which was administered to 8 of the patients during CPB, reduced platelet activation as measured by a reduction in the release of BTG and also attenuated the consumption of VIII: C. It had no effect on pulmonary endothelial damage as measured by the ratio of vWF: Ag to vWF: RiCoF.

Keywords

Factor VIII - Cardiopulmonary bypass - Prostacyclin - Endothelium
 

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