Changes in Factor VIII Proteins After Cardiopulmonary Bypass in Man Suggest Endothelial Damage

D K Jones; R Luddington; T W Higenbottam; J Scott; N Cavarocchi; D Reardon; J Calvin; J Wallwork

doi:10.1055/s-0038-1647029

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1988; 60(02): 199-204
DOI: 10.1055/s-0038-1647029

Original Article

Schattauer GmbH Stuttgart

Changes in Factor VIII Proteins After Cardiopulmonary Bypass in Man Suggest Endothelial Damage

D K Jones

¹The Department of Respiratory Physiology, Papworth Hospital, Cambridge, England

,

R Luddington

³The Department of Clinical Haematology, Addenbrookes Hospital, Cambridge, England

,

T W Higenbottam

¹The Department of Respiratory Physiology, Papworth Hospital, Cambridge, England

,

J Scott

¹The Department of Respiratory Physiology, Papworth Hospital, Cambridge, England

,

N Cavarocchi

²The Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, England

,

D Reardon

³The Department of Clinical Haematology, Addenbrookes Hospital, Cambridge, England

,

J Calvin

⁴The Department of Biochemistry, Addenbrookes Hospital, Cambridge, England

,

J Wallwork

²The Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, England

› Author Affiliations

Abstract

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Summary

16 patients undergoing coronary artery bypass grafting using cardiopulmonary bypass (CPB) had blood samples taken at various times before, during and up to 1 week after surgery for estimation of beta-thromboglobulin (BTG), alpha- 1-antichymo- trypsin (ACT), factor VIII procoagulant protein (VIII:C), von Willebrand factor antigen (vWF:Ag) and ristocetin co-factor (vWFiRiCoF). vWF:Ag and vWF:RiCoF rose during and following surgery in a different manner to ACT. At 1 week there was a significantly disproportionate rise in vWF: Ag compared to vWFiRiCoF which suggested a degree of pulmonary endothelial damage.

Prostacyclin, which was administered to 8 of the patients during CPB, reduced platelet activation as measured by a reduction in the release of BTG and also attenuated the consumption of VIII: C. It had no effect on pulmonary endothelial damage as measured by the ratio of vWF: Ag to vWF: RiCoF.

Keywords

Factor VIII - Cardiopulmonary bypass - Prostacyclin - Endothelium

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References

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