Thromb Haemost 1988; 60(02): 262-266
DOI: 10.1055/s-0038-1647042
Original Article
Schattauer GmbH Stuttgart

Plasminogen Activators in the Intestine of Patients with Inflammatory Bowel Disease

P A F de Bruin
1   The Department of Gastroenterology and Hepatology, University Hospital, Health Research Division TNO, Leiden, The Netherlands
,
G Crama-Bohbouth
1   The Department of Gastroenterology and Hepatology, University Hospital, Health Research Division TNO, Leiden, The Netherlands
,
H W Verspaget
1   The Department of Gastroenterology and Hepatology, University Hospital, Health Research Division TNO, Leiden, The Netherlands
,
J H Verheijen
2   Gaubius Institute, Health Research Division TNO, Leiden, The Netherlands
,
G Dooijewaard
1   The Department of Gastroenterology and Hepatology, University Hospital, Health Research Division TNO, Leiden, The Netherlands
,
I T Weterman
1   The Department of Gastroenterology and Hepatology, University Hospital, Health Research Division TNO, Leiden, The Netherlands
,
C B H W Lamers
1   The Department of Gastroenterology and Hepatology, University Hospital, Health Research Division TNO, Leiden, The Netherlands
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received 27. Januar 1988

Accepted after revision 14. Juni 1988

Publikationsdatum:
28. Juni 2018 (online)

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Summary

Plasminogen activators were determined in intestinal tissue, obtained after surgery from patients with Crohn’s disease and ulcerative colitis, and compared with normal intestinal tissue from colorectal cancer patients.

The activity and quantity of tissue-plasminogen activator (t-PA) was found to decrease with the severity of inflammation in the patients with inflammatory bowel disease. Urokinase (u-PA) activity, however, was not changed compared with controls or in relation with severity of inflammation. In contrast, the level of u-PA antigen was found to be increased significantly in the inflammatory bowel disease tissues and was also related with severity of inflammation. The difference between u-PA activity and antigen in inflammatory bowel disease tissue could be attributed to an increase in inactive pro-u-PA and u-PA-inhibitor complexes.

This increase in u-PA and the concomitant decrease in t-PA, are similar to those found in premalignant colonic adenomas, and might be related to the known increased cancer risk in inflammatory bowel disease.