Haemostasis by Immunisation : Wishful Thinking?^[*]

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These considerations are respectfully , dedicated to professor M. verstraete on the occasion of his 65th birthday.

• References

• 1 Cosimi AB, Colvin R, Burton R. et al Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts. N Engl J Med 1981; 305: 308-314
• 2 Kreis H, Chkoff N, Chatenoud L. et al Prolonged administration of a monoclonal anti-T3 cell antibody (Orthoclone OKT3) to kidney allograft recipients. Transplant Proc 1985; 17: 2734-2736
• 3 Jaffers GJ, Fuller TC, Cosimi AB. et al Monoclonal antibody therapy. Anti-idiotypic and non-anti-idiotypic antibodies to OKT3 arising despite intense immunosuppression. Transplantation 1986; 41: 572-578
• 4 Durrant LG, Robins RA, Marksman RA. et al Abrogation of antibody responses in rats to murine monoclonal antibody 791T/36 by treatment with daunomycin-cis-aconityl-791T/36 conjugates. Cancer Immunol Immunother 1989; 28: 37-42
• 5 Wilkinson I, Jackson C-JC, Lang GM. et al Tolerance induction in mice by conjugates of monoclonal immunoglobulins and mono-methoxypolyethylene glycol. Transfer of tolerance by T cells and T cell extracts. J Immunol 1987; 139: 326-331
• 6 Durrant LG, Byers VS, Scannon PJ. et al Humoral immune responses to XMMCO-791-RTA immunotoxin in colorectal cancer patients. Clin Exp Immunol 1989; 75: 258-264
• 7 Koprowski H, Herlyn D, Lubeck M. et al Human anti-idiotype antibodies in cancer patients: Is the modulation of the immune response beneficial for the patient. Proc Natl Acad Sci USA 1984; 81: 216-219
• 8 Nepom GT, Nelson KA, Holbeck SL. et al Induction of immunity to a human tumor marker by in vitro administration of anti-idiotypic antibodies in mice. Proc Natl Acad Sci 1984; 81: 2864-2867
• 9 Campbell MJ, Caroll W, Kon S. et al Idiotype vaccination against murine B cell Lymphoma. Humoral and cellular responses elicited by tumor-derived immunoglobulin M and its molecular subunits. J Immunol 1987; 139: 2825-2833