Summary
The variations of FVII, PAI-1, TAT complexes, fibrinopeptide A, D-Dimers and beta
thromboglobulin plasma levels were studied on 30 sedentary men, smokers and non-smokers,
who were admitted to a 6 months’ program of physical training and smoking cessation.
After 3 months of intervention, sustained physical training was associated with the
decrease of FVII and PAI-1 levels. Mild exercise performed during a second 3-month
period could maintain normal FVII and PAI-1 activities but participants who stopped
the training increased their FVII and PAI-1 plasma levels. FVII was not influenced
by smoking habits. Smoking cessation seemed to slightly potentiate the decrease of
PAI-1 levels associated with mild exercise. Overweight, FVII and PAI-1 levels were
correlated and the weight reduction induced by training was related to the changes
in the factors. In smokers, physical exercise was associated with a significant increase
of hemostatic markers. This exercise-induced variation disappeared after 3 months
of intervention in participants who stopped smoking and reappeared in those who smoked
again after 6 months of intervention. This finding was not influenced by the physical
training program.
