Normal Platelet Function, but Increased Platelet Activation In Vivo in Diabetic Patients

Letizia Tomaselli; Chiara Cerletti; Giovanni de Gaetano; Alberto Notarbartolo; Giovanni Davì; Mario Pupillo

doi:10.1055/s-0038-1647366

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1990; 64(04): 604
DOI: 10.1055/s-0038-1647366

Letter to the Editor

Schattauer GmbH Stuttgart

Normal Platelet Function, but Increased Platelet Activation In Vivo in Diabetic Patients

Letizia Tomaselli

Istituto di Ricerche Farmacologiche Mario Negri Consorzio Mario Negri Sud 66030 Santa Maria Imbaro, Italy

,

Chiara Cerletti

Istituto di Ricerche Farmacologiche Mario Negri Consorzio Mario Negri Sud 66030 Santa Maria Imbaro, Italy

,

Giovanni de Gaetano

Istituto di Ricerche Farmacologiche Mario Negri Consorzio Mario Negri Sud 66030 Santa Maria Imbaro, Italy

,

Alberto Notarbartolo

¹Patologia Medica, Università di Palermo, Italy

,

Giovanni Davì

²Cattedra di Ematologia, Università di Chieti, Italy

,

Mario Pupillo

³Ospedale Civile “F. Renzetti”, Lanciano Italy

› Author Affiliations

Abstract

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References

References
1 Mustard JF, Packham MA. Platelets and diabetes mellitus. N Engl J Med 1984; 311: 665-667
2 Rao KA, Goldberg RF, Walsh PN. Platelet coagulant activities in diabetes mellitus: evidence for relationship between platelet coagulant hyperactivity and platelet volume. J Lab Clin Med 1984; 103: 82-92
3 Kazmier FJ, Bowie EJ W, O’Fallow WM, Zimmermann BR, Osmundson PJ, Palumbo PJ. A prospective study of peripheral occlusive arterial disease in diabetes. IV. Platelet and plasma functions. Mayo Clin Proc 1981 56. 243-253
4 Allessandrini P, McRae J, Feman S, FitzGerald GA. Thromboxane biosynthesis and platelet function in type I diabetes mellitus. N Engl J Med 1988; 319: 208-212
5 Davi G, Catalano I, Perez T, Notarbartolo A, Strano A, Ciabattoni G, Patrono C. Increased urinary excretion of 11-dehydro-thromboxane B₂ in type 2 diabetes mellitus. Thromb Haemostas 1989; 62: 244
6 FitzGerald GA, Smith B, Pedersen AK, Brash AR. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. N Engl J Med 1984; 310: 1065-1068
7 Cerletti C, Minoldo S, Bucchi F, Del Maschio A, de Gaetano G. Requirement of ADP for arachidonic acid-induced platelet aggregation: studies with selective thromboxane-synthase inhibitors. Biochem Pharmacol 1986; 35: 1201-1203
8 Ciabattoni G, Maclouf J, Catella F, FitzGerald GA, Patrono C. Radioimmunoassay of 11-dehydrothromboxane B2 in human plasma and urine. Biochim Biophys Acta 1987; 918: 293-297
9 Di Minno G, Silver MJ, Cerbone AM, Murphy S. Trial of repeated low-dose aspirin in diabetic angiopathy. Blood 1986; 68: 886-891