The Decreased Circulating Platelet Mass and Its Relation to Bleeding Time in Chronic Renal Failure

E Michalak; B Walkowiak; M Paradowski; C S Cierniewski

doi:10.1055/s-0038-1647445

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1991; 65(01): 011-014
DOI: 10.1055/s-0038-1647445

Original Article

Schattauer GmbH Stuttgart

The Decreased Circulating Platelet Mass and Its Relation to Bleeding Time in Chronic Renal Failure

Authors

E Michalak

^*The Department of Nephrology, Military Medical School, Lodz, Poland
B Walkowiak

^**The Department of Biophysics, Military Medical School, Lodz, Poland
M Paradowski

^***The Department of Medical School, Laboratory Unit, Military Medical School, Lodz, Poland
C S Cierniewski

^**The Department of Biophysics, Military Medical School, Lodz, Poland

Abstract

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Summary

The mean platelet volume, measured optically and by the electrical impedance method, was analysed in the patients with chronic renal failure. All parameters describing the circulating platelet biomass except the platelet volume heterogeneity were decreased in these patients. There is a strong inverse relation between the Ivy bleeding time and the platelet mass in the patient group.

Our results indicate that the smaller platelets circulating in the patients with chronic renal failure may contribute to the uremic bleeding diathesis, and disturbed thrombocytopoiesis occurs in chronic renal failure.

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References

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