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Thromb Haemost 1988; 59(03): 357-359
DOI: 10.1055/s-0038-1647495
Original Article
Schattauer GmbH Stuttgart

The Bleeding Time Is Inversely Related to Megakaryocyte Nuclear DNA Content and Size in Man

S Dalby Kristensen
The University Departments of Medicine, Royal Hallamshire Hospital, Sheffield and King’s College Hospital London, UK
,
Philip M W Bath
The University Departments of Medicine, Royal Hallamshire Hospital, Sheffield and King’s College Hospital London, UK
,
John F Martin
The University Departments of Medicine, Royal Hallamshire Hospital, Sheffield and King’s College Hospital London, UK
› Author Affiliations
Further Information

Publication History

Received 31 August 1987

Accepted after revision 04 January 1988

Publication Date:
29 June 2018 (online)

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Summary

The relation between the bleeding time and the megakaryocyte nuclear DNA content and size was evaluated in eleven consecutive patients with normal steady state thrombopoiesis undergoing thoracotomy. A statistically significant inverse correlation was found between the bleeding time and both megakaryocyte DNA content (r = −0.71, p <0.05), megakaryocyte total size (r = ‒0.58, p <0.05), megakaryocyte cytoplasmic size (r = −0.64, p <0.05) and megakaryocyte nuclear size (r = −0.58, p <0.05). The megakaryocyte total size and the megakaryocyte cytoplasmic size were statistically significantly larger in men than women (p <0.02 and p <0.03 respectively). Changes in the megakaryocytes in the bone marrow are associated with changes in primary haemostasis in normal individuals.

Keywords

Bleeding time - Megakaryocytes - Platelets - Platelet volume
 

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